发明公开
EP1187841A1 METHOD FOR ENHANCED PROTEIN STABILIZATION AND PRODUCTION OF CELL LINES USEFUL FOR PRODUCTION OF SUCH STABILIZED PROTEINS
审中-公开
方法的改进稳定蛋白和细胞系生产这种稳定的蛋白质的生产
- 专利标题： METHOD FOR ENHANCED PROTEIN STABILIZATION AND PRODUCTION OF CELL LINES USEFUL FOR PRODUCTION OF SUCH STABILIZED PROTEINS
- 专利标题（中）： 方法的改进稳定蛋白和细胞系生产这种稳定的蛋白质的生产
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申请号： EP00930813.1申请日： 2000-05-18
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公开(公告)号： EP1187841A1公开(公告)日： 2002-03-20
- 发明人: DEES, H., Craig , SMOLIK, John
- 申请人： Photogen, Inc.
- 申请人地址： 7327 Oak Ridge Highway Knoxville, TN 37931 US
- 专利权人： Photogen, Inc.
- 当前专利权人： Photogen, Inc.
- 当前专利权人地址： 7327 Oak Ridge Highway Knoxville, TN 37931 US
- 代理机构： Hill, Christopher Michael
- 优先权： US136676P 19990528; US543479 20000406
- 国际公布： WO0073319 20001207
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C12P21/06 ; C12P21/04 ; C12P19/34 ; H01J29/10 ; H01J5/50 ; H01J5/48
摘要：
A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is also directed to methods for selection or engineering of cell lines yielding such enhanced stabilized products. More specifically, example embodiments of the present invention are directed to methods for enhancing production of a viral agent, production of cell lines exhibiting permanent genetic modification, production of permissive eucaryotic cell lines, enhancing functional recombinant product yield, and the products of such methods.
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