公开(公告)号：EP1210078A4

公开(公告)日：2004-06-09

申请号：EP00959216

申请日：2000-08-10

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  SCOTT TIMOTHY ,  SMOLIK JOHN ,  WACHTER ERIC ,  FISHER WALTER

IPC分类号： A61B18/20 ,  A61K20060101 ,  A61K9/00 ,  A61K9/08 ,  A61K9/12 ,  A61K31/35 ,  A61K31/352 ,  A61K41/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/48 ,  A61N5/06 ,  A61P1/00 ,  A61P11/00 ,  A61P13/00 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P31/00 ,  A61P33/00 ,  A61P35/00 ,  A61P43/00 ,  C07D311/82 ,  C07D311/88

CPC分类号： A61K41/0057 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  C07D311/82

公开(公告)号：EP1284727A4

公开(公告)日：2004-06-02

申请号：EP01920579

申请日：2001-03-20

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  SCOTT TIMOTHY ,  WACHTER ERIC ,  FISHER WALTER ,  SMOLIK JOHN

IPC分类号： A61K9/06 ,  A61B17/00 ,  A61B17/22 ,  A61F7/00 ,  A61K9/00 ,  A61K9/08 ,  A61K9/107 ,  A61K9/12 ,  A61K9/20 ,  A61K9/48 ,  A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K41/00 ,  A61K47/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61K47/34 ,  A61K47/42 ,  A61K47/44 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61N5/06 ,  A61P1/00 ,  A61P1/04 ,  A61P5/00 ,  A61P9/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P31/00 ,  A61P31/10 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P43/00 ,  C07D311/82 ,  A61P17/06

CPC分类号： A61K31/352 ,  A61B2017/00057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0019 ,  A61K41/0038 ,  A61K41/0057 ,  A61K41/0071 ,  A61K41/008 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/6803 ,  A61K49/0041 ,  A61K49/0433 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y10T436/153333 ,  Y10T436/19 ,  Y10T436/193333

摘要： New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

公开(公告)号：EP1192450A1

公开(公告)日：2002-04-03

申请号：EP99967402.1

申请日：1999-12-16

申请人： Photogen, Inc.

发明人： DEES, H., Craig ,  SCOTT, Timothy ,  SMOLIK, John ,  WACHTER, Eric

IPC分类号： G01N23/00

CPC分类号： A61K41/0038 ,  A61K49/0433 ,  Y10S436/813 ,  Y10S436/819

摘要： A high energy phototherapeutic agents or radiosensitizer agent comprised of a halogenated xanthene, or an agent that exhibits a preference for concentration in biologically sensitive structures in diseased tissue, and methods of treating and imaging using radiosensitizer agents in diseased tissue.

公开(公告)号：EP1292298B1

公开(公告)日：2007-03-28

申请号：EP01926602.2

申请日：2001-04-03

申请人： Photogen, Inc.

发明人： DEES, H, Craig ,  SCOTT, Timothy ,  WACHTER, Eric ,  FISHER, Walter ,  SMOLIK, John

IPC分类号： A61K31/352 ,  A61K51/04 ,  A61K41/00

CPC分类号： A61K41/0038 ,  A61B2017/00057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0019 ,  A61K31/352 ,  A61K41/0057 ,  A61K41/008 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/6803 ,  A61K49/0041 ,  A61K49/0433 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y10S436/813 ,  Y10S436/819

摘要： New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative.

公开(公告)号：EP1292298A4

公开(公告)日：2003-06-25

申请号：EP01926602

申请日：2001-04-03

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  SCOTT TIMOTHY ,  WACHTER ERIC ,  FISHER WALTER ,  SMOLIK JOHN

IPC分类号： C07D311/82 ,  A61B17/00 ,  A61B17/22 ,  A61F7/00 ,  A61K9/00 ,  A61K9/02 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K9/12 ,  A61K9/20 ,  A61K9/48 ,  A61K31/352 ,  A61K41/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61N5/06 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P43/00 ,  A61K51/04

CPC分类号： A61K41/0038 ,  A61B2017/00057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0019 ,  A61K31/352 ,  A61K41/0057 ,  A61K41/008 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/6803 ,  A61K49/0041 ,  A61K49/0433 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y10S436/813 ,  Y10S436/819

摘要： New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative.

公开(公告)号：EP1210078A1

公开(公告)日：2002-06-05

申请号：EP00959216.3

申请日：2000-08-10

申请人： Photogen, Inc.

发明人： DEES, H., Craig ,  SCOTT, Timothy ,  SMOLIK, John ,  WACHTER, Eric ,  FISHER, Walter

IPC分类号： A61K31/35 ,  C07D311/88

CPC分类号： A61K41/0057 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  C07D311/82

摘要： New photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene. The halogenated xanthenes constitute a family of potent photosensitizers that become photoactivated upon illumination of the treatment site with visible wavelengths of light. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs; the mouth and digestive tract and related organs; the urinary and reproductive tracts and related organs; the respiratory tract and related organs; various other internal or external tissue surfaces, such as tissue surfaces exposed during surgery; and for treatment of a variety of conditions related to microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid or aerosol delivery vehicles.

公开(公告)号：EP1032321A1

公开(公告)日：2000-09-06

申请号：EP97948121.5

申请日：1997-10-27

申请人： Photogen, Inc.

发明人： WACHTER, Eric, A. ,  FISHER, Walter, G. ,  DEES, H., Craig

IPC分类号： A61B19/00 ,  A61K49/00

CPC分类号： A61N5/062 ,  A61B2017/00057 ,  A61K41/008 ,  A61K49/0017 ,  A61K49/0039 ,  A61K49/0043 ,  B82Y15/00

摘要： A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method comprises the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the photo-active molecular agents in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention also provides a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

摘要翻译： 一种用于成像特定体积的植物或动物组织的方法，其中所述植物或动物组织包含至少一种光敏分子试剂。 该方法包括用足以促进包含在植物或动物组织的特定体积中的光敏分子试剂的同时双光子激发的光处理植物或动物组织的特定体积的步骤， 在植物或动物组织的特定体积中的至少一种光敏分子试剂，由此产生至少一种光激活分子试剂，其中所述至少一种光激活分子试剂发射能量，检测由所述光激活分子试剂发射的能量 至少一种光敏分子试剂，并且产生检测到的能量信号，该能量信号是植物或动物组织的特定体积的特征。 本发明还提供了用于成像特定体积的材料的方法，其中所述材料包含至少一种光敏分子试剂。

公开(公告)号：EP0977592A1

公开(公告)日：2000-02-09

申请号：EP97946336.1

申请日：1997-10-28

申请人： Photogen, Inc.

发明人： FISHER, Walter, G. ,  WACHTER, Eric, A. ,  DEES, H., Craig

IPC分类号： A61K41/00

CPC分类号： A61K41/0057 ,  A61B2017/00057 ,  A61K41/008 ,  A61N5/062 ,  B82Y15/00

摘要： A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.

摘要翻译： 一种处理特定体积的植物或动物组织的方法，包括用至少一种光敏分子试剂处理植物或动物组织的步骤，其中特定体积的植物或动物组织保留至少一部分 所述至少一种光敏分子试剂，然后用足以促进保留在所述至少一种光敏分子试剂中的所述至少一种光敏分子试剂中的至少一种的同时双光子激发的光处理所述植物或动物组织的特定体积 特定体积的植物或动物组织，其中所述至少一种光敏分子试剂在植物或动物组织的特定体积中变得具有活性。 还公开了用于治疗植物或动物组织中的癌症的方法以及用于在特定体积的材料中生产至少一种光活化分子试剂的方法。

公开(公告)号：EP1265546A4

公开(公告)日：2006-08-09

申请号：EP01916441

申请日：2001-03-07

申请人： PHOTOGEN INC

发明人： FISHER WALTER ,  WACHTER ERIC

IPC分类号： G01N21/17 ,  A61B5/00 ,  A61B17/00 ,  A61K41/00 ,  A61K49/00 ,  A61M25/00 ,  A61M25/01 ,  A61N1/05 ,  A61N5/06 ,  B23K26/06 ,  G01N21/47 ,  G02B21/06 ,  A61B19/00

CPC分类号： A61K41/008 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/0068 ,  A61B2017/00053 ,  A61B2017/00057 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61K49/0017 ,  A61M25/0041 ,  A61M25/0133 ,  A61N1/056 ,  A61N5/062 ,  A61N2005/0644 ,  B23K26/0624 ,  B82Y15/00 ,  G01N21/4795

摘要： Methods and apparatus directed to using modulation to substantially improve detection limits in optical imaging, and to substantially improve the performance of various optical imaging systems. Such modulation is achieved using a modulated light source (40), a modulation frequency reference (42), a detector (10), and a demodulator (46). The modulated light source may comprise a light source emitting an inherently modulated output; or, this modulated light source may comprise a separate optical modulator and a continuous wave, modulated, or pulsed light source configured to impose a modulation in the output of light source. Methods for imaging are also disclosed.

公开(公告)号：EP1187555A4

公开(公告)日：2004-12-01

申请号：EP00937691

申请日：2000-05-23

申请人： PHOTOGEN INC

发明人： FISHER WALTER ,  SMOLIK JOHN ,  DEES H CRAIG ,  WACHTER ERIC

IPC分类号： G01N21/64 ,  A61B5/00 ,  A61B5/103 ,  A61B10/00 ,  A61B6/00

CPC分类号： A61B5/444 ,  A61B5/0059 ,  A61B5/0091

摘要： A method and apparatus for diagnosis or imaging of a particular volume of material, including the steps of treating the particular volume of material with light sufficient to promote a multi-photon excitation of at least one photo-active agent contained on or within the particular volume of the material, wherein the at least one photo-active agent becomes active in the particular volume of the material, thereby resulting in the production of an optical signal, and wherein such optical signal is captured in electronic form for diagnosis or imaging of the particular volume of material.