发明公开
- 专利标题： HCV/BVDV CHIMERIC GENOMES AND USES THEREOF
- 专利标题（中）： HCV / BVDV嵌合基因组，并使用
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申请号： EP00938165.8申请日： 2000-06-02
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公开(公告)号： EP1187927A2公开(公告)日： 2002-03-20
- 发明人: NAM, Jae-Hwan , BUKH, Jens , EMERSON, Suzanne, U. , PURCELL, Robert, H.
- 申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 申请人地址： c/o National Institutes of Health,Office of Technology Transfer,6011 Executive Boulevard,Suite 325 Rockville, MD 20852-3804 US
- 专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： c/o National Institutes of Health,Office of Technology Transfer,6011 Executive Boulevard,Suite 325 Rockville, MD 20852-3804 US
- 代理机构： Gervasi, Gemma, Dr.
- 优先权： US137817P 19990604
- 国际公布： WO0075352 20001214
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C12N7/01 ; C07K14/18
摘要：
The present invention relates to molecular approaches to the production of nucleic acid sequences which comprise the genomes of chimeric hepatitis C virus-bovine viral diarrhea viruses (HCV-BVDV). The invention also relates to the use of these chimeric nucleic acid sequences to produce chimeric virions in cells and the use of these chimeric virions in HCV antibody neutralization assays, and for the development of vaccines and therapeutics for HCV.
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