-
公开(公告)号：EP0998567A2
公开(公告)日：2000-05-10
申请号：EP98935702.5
申请日：1998-07-16
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/525 , C07K2319/00 , C12N7/00 , C12N2770/24221 , C12N2770/24222
摘要： The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
-
2.发明授权CLONED GENONE OF INFECTIOUS HEPATITIS C VIRUS OF GENOTYPE 2a AND USES THEREOF 有权感染性丙肝病毒基因型2A和克隆基因组及其用途
公开(公告)号：EP1185664B1
公开(公告)日：2007-05-16
申请号：EP00938146.8
申请日：2000-06-02
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2770/24222
摘要： The present invention discloses nucleic acid sequence which encodes infectious hepatitis C virus of strain HC-J6CH, genotype 2a, and the use of the sequence, and polypeptides encoded by all or part of the sequence, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
-
公开(公告)号：EP1185665A1
公开(公告)日：2002-03-13
申请号：EP00939534.4
申请日：2000-06-02
CPC分类号： C07K14/005 , C07K2319/00 , C12N2770/24222
摘要： The present invention relates to nucleic acid sequence which comprises the genome of an infectious GB virus B clone. The invention also relates to the use of the nucleic acid sequence of the infectious GB virus B clone to indirectly study the molecular properties of HCV, and in the production of HCV/GBV-B chimeras. The invention further relates to the use of the infectious nucleic acid sequence of GB virus B clone and the HCV/GBV-B chimeras in the development of vaccines and therapeutics for HCV.
-
4.发明公开CLONED GENONE OF INFECTIOUS HEPATITIS C VIRUS OF GENOTYPE 2a AND USES THEREOF 有权感染性丙肝病毒基因型2A和克隆基因组及其用途
公开(公告)号：EP1185664A2
公开(公告)日：2002-03-13
申请号：EP00938146.8
申请日：2000-06-02
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2770/24222
摘要： The present invention discloses nucleic acid sequence which encodes infectious hepatitis C virus of strain HC-J6CH, genotype 2a, and the use of the sequence, and polypeptides encoded by all or part of the sequence, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
-
公开(公告)号：EP1185665B1
公开(公告)日：2008-09-10
申请号：EP00939534.4
申请日：2000-06-02
CPC分类号： C07K14/005 , C07K2319/00 , C12N2770/24222
-
公开(公告)号：EP1187927A2
公开(公告)日：2002-03-20
申请号：EP00938165.8
申请日：2000-06-02
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N7/00 , C12N15/86 , C12N2770/24222 , C12N2770/24322 , C12N2770/24344
摘要： The present invention relates to molecular approaches to the production of nucleic acid sequences which comprise the genomes of chimeric hepatitis C virus-bovine viral diarrhea viruses (HCV-BVDV). The invention also relates to the use of these chimeric nucleic acid sequences to produce chimeric virions in cells and the use of these chimeric virions in HCV antibody neutralization assays, and for the development of vaccines and therapeutics for HCV.
-
7.发明公开NUCLEOTIDE AND AMINO ACID SEQUENCES OF HYPERVARIABLE REGION 1 OF THE ENVELOPE 2 GENE OF HEPATITIS C VIRUS 失效HYPER VARIABELEN REGION作者：丙型肝炎病毒病例-2基因的核苷酸序列和氨基酸序列
公开(公告)号：EP0832114A2
公开(公告)日：1998-04-01
申请号：EP96919172.0
申请日：1996-06-05
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222
摘要： The nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of 49 isolates of hepatitis C are disclosed. The invention relates to the use of these sequences to design proteins and nucleic acid sequences useful in diagnostic methods and vaccines.
-
公开(公告)号：EP2004684A2
公开(公告)日：2008-12-24
申请号：EP07753780.1
申请日：2007-03-22
申请人： GENimmune N.V. , The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services
CPC分类号： C07K16/109 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to anti-HCV antibodies and more specifically to neutralizing anti-HCV antibodies and their variable and complementarity determining regions (CDR). In particular, the neutralizing anti-HCV antibodies are neutralizing anti-HCV envelope protein 1 (HCV E1) antibodies. Also subject of the invention are compositions comprising these antibodies, CDRs or variable regions, and compounds comprising at least one of the CDRs or variable regions of said antibodies. Further subject of the invention are the application of any of said antibodies, CDRs, variable regions or compounds in HCV prophylaxis, therapy, and diagnosis, as well as methods for producing the antibodies.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.02 秒)
