发明公开
EP1210405A2 CARDIOMYOCYTES WITH ENHANCED PROLIFERATIVE POTENTIAL, AND METHODS FOR PREPARING AND USING SAME
审中-公开
具有增加，增殖潜力及其制备方法和用途的心肌细胞
- 专利标题： CARDIOMYOCYTES WITH ENHANCED PROLIFERATIVE POTENTIAL, AND METHODS FOR PREPARING AND USING SAME
- 专利标题（中）： 具有增加，增殖潜力及其制备方法和用途的心肌细胞
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申请号： EP00941542.3申请日： 2000-06-19
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公开(公告)号： EP1210405A2公开(公告)日： 2002-06-05
- 发明人: FIELD, Loren, J. , PASUMARTHI, Kishore Babu S.
- 申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.
- 申请人地址： Suite 100,1100 Waterway Boulevard Indianapolis, IN 46202 US
- 专利权人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.
- 当前专利权人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.
- 当前专利权人地址： Suite 100,1100 Waterway Boulevard Indianapolis, IN 46202 US
- 代理机构： Atkinson, Peter Birch
- 优先权： US139942P 19990618
- 国际公布： WO0078119 20001228
- 主分类号： C12N1/00
- IPC分类号： C12N1/00 ; C12N15/63 ; C12N15/85 ; C07H21/04
摘要：
Described are methods in vitro and in vivo which involve the use of increased cyclin D2 activity to activate the cell cycle of cardiomyocytes as a baseline measure and/or in response to stimuli. Also described are vectors useful for these purposes, and cardiomyocyte cells exhibiting an activated cell cycle. Transgenic cyclin D2 animal models are also described.
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