专利检索 ap:("ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.") AND inv:"FIELD, Loren, J." 第 1 页

1.

发明公开
MULTIPOTENT CELL AND CARDIOMYOCYTE CELL POPULATIONS, AND ROUTES TO AND USES OF SAME 审中-公开
标题翻译：多POTENT细胞和细胞群KARDIOMYOCYTE，生产及其应用

公开(公告)号：EP1265987A2

公开(公告)日：2002-12-18

申请号：EP01916536.4

申请日：2001-03-12

申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.

发明人： FIELD, Loren, J.

IPC分类号： C12N5/06 , C12N5/10 , C12N15/10 , C12N15/66 , C12N15/67 , C07K14/47 , G01N33/48 , A61L27/24

CPC分类号： C12N5/0657 , A61K35/12 , C12N2506/02 , C12N2510/00

摘要： Described are conduction cardiomyocyte-enriched cellular populations, and methods and materials for obtaining the same. The populations may be used to engraft mammalian myocardial tissue, for example to provide biological pacemakers. Also described are restorative cellular myocardial tissue, for example to provide biological pacemakers. Also described are restorative cellular myocardial grafts for improving the contractile function of injured segments of myocardium, and articles adapted for heart implantation (e.g. conductive pacemaker leads), which includes coatings of viable cardiomyocytes and optionally a carrier for the cardiomyocytes.

2.

发明公开
CARDIOMYOCYTES WITH ENHANCED PROLIFERATIVE POTENTIAL, AND METHODS FOR PREPARING AND USING SAME 审中-公开
标题翻译：具有增加，增殖潜力及其制备方法和用途的心肌细胞

公开(公告)号：EP1210405A2

公开(公告)日：2002-06-05

申请号：EP00941542.3

申请日：2000-06-19

申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.

发明人： FIELD, Loren, J. , PASUMARTHI, Kishore Babu S.

IPC分类号： C12N1/00 , C12N15/63 , C12N15/85 , C07H21/04

CPC分类号： C07K14/4738 , A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2217/20 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A61K38/00 , C12N5/0657 , C12N15/8509 , C12N2510/00 , C12N2799/021 , C12N2830/007 , C12N2830/008 , C12N2830/38 , C12N2830/85 , C12N2840/20 , C12N2840/203

摘要： Described are methods in vitro and in vivo which involve the use of increased cyclin D2 activity to activate the cell cycle of cardiomyocytes as a baseline measure and/or in response to stimuli. Also described are vectors useful for these purposes, and cardiomyocyte cells exhibiting an activated cell cycle. Transgenic cyclin D2 animal models are also described.