发明授权
- 专利标题： CRYSTAL STRUCTURE OF A DEACETYLASE AND INHIBITORS THEREOF
- 专利标题（中）： 晶体结构的脱乙酰基酶及其抑制剂的
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申请号： EP00968344.2申请日： 2000-09-08
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公开(公告)号： EP1212357B1公开(公告)日： 2007-05-02
- 发明人: PAVLETICH, Nikola , FINNIN, Michael , DONIGIAN, Jill , RICHON, Victoria , RIFKIND, Richard, A. , MARKS, Paul, A. , BRESLOW, Ronald
- 申请人： Sloan-Kettering Institute For Cancer Research , The Trustees of Columbia University in the City of New York
- 申请人地址： 1275 York Avenue New York, New York 10021 US
- 专利权人： Sloan-Kettering Institute For Cancer Research,The Trustees of Columbia University in the City of New York
- 当前专利权人： Sloan-Kettering Institute For Cancer Research,The Trustees of Columbia University in the City of New York
- 当前专利权人地址： 1275 York Avenue New York, New York 10021 US
- 代理机构： Kirkham, Nicholas Andrew
- 优先权： US152753P 19990908
- 国际公布： WO2001018045 20010315
- 主分类号： C07K14/00
- IPC分类号： C07K14/00 ; C12N9/16 ; G01N33/50
摘要：
The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.
公开/授权文献
- EP1212357A1 CRYSTAL STRUCTURE OF A DEACETYLASE AND INHIBITORS THEREOF 公开/授权日：2002-06-12
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