专利检索 ap:("Sloan-Kettering Institute For Cancer Research" OR "The Trustees of Columbia University in the City of New York") AND inv:"PAVLETICH, Nikola" 第 1 页

1.

发明授权
CRYSTAL STRUCTURE OF A DEACETYLASE AND INHIBITORS THEREOF 有权
标题翻译：晶体结构的脱乙酰基酶及其抑制剂的

公开(公告)号：EP1212357B1

公开(公告)日：2007-05-02

申请号：EP00968344.2

申请日：2000-09-08

申请人： Sloan-Kettering Institute For Cancer Research , The Trustees of Columbia University in the City of New York

发明人： PAVLETICH, Nikola , FINNIN, Michael , DONIGIAN, Jill , RICHON, Victoria , RIFKIND, Richard, A. , MARKS, Paul, A. , BRESLOW, Ronald

IPC分类号： C07K14/00 , C12N9/16 , G01N33/50

CPC分类号： C12N9/16

摘要： The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.

2.

发明公开
CRYSTAL STRUCTURE OF A DEACETYLASE AND INHIBITORS THEREOF 有权
标题翻译：晶体结构的脱乙酰基酶及其抑制剂的

公开(公告)号：EP1212357A1

公开(公告)日：2002-06-12

申请号：EP00968344.2

申请日：2000-09-08

申请人： Sloan-Kettering InstituteFor Cancer Research , THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： PAVLETICH, Nikola , FINNIN, Michael , DONIGIAN, Jill , RICHON, Victoria , RIFKIND, Richard, A. , MARKS, Paul, A. , BRESLOW, Ronald

IPC分类号： C07K14/00 , G01N33/573

CPC分类号： C12N9/16

摘要： The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.