发明公开
EP1218381A2 AMINO SUBSTITUTED PYRAZOLO 1,5,-a]-1,5-PYRIMIDINES AND PYRAZOLO 1,5-a]-1,3,5-TRIAZINES
有权
氨基 - 替代吡唑并[1,5-A] -1,5-二吡啶并[1,2-a] -1,3,5-三嗪
- 专利标题： AMINO SUBSTITUTED PYRAZOLO 1,5,-a]-1,5-PYRIMIDINES AND PYRAZOLO 1,5-a]-1,3,5-TRIAZINES
- 专利标题（中）： 氨基 - 替代吡唑并[1,5-A] -1,5-二吡啶并[1,2-a] -1,3,5-三嗪
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申请号： EP00967132.2申请日： 2000-09-29
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公开(公告)号： EP1218381A2公开(公告)日： 2002-07-03
- 发明人: DARROW, James W. , DE LOMBAERT, Stephane , BLUM, Charles , TRAN, Jennifer , GIANGIORDANO, Mark , GRIFFITH, David Andrew , CARPINO, Philip Albert
- 申请人： NEUROGEN CORPORATION , PFIZER INC.
- 申请人地址： 35 N.E. Industrial Road Branford, CT 06405 US
- 专利权人： NEUROGEN CORPORATION,PFIZER INC.
- 当前专利权人： NEUROGEN CORPORATION,PFIZER INC.
- 当前专利权人地址： 35 N.E. Industrial Road Branford, CT 06405 US
- 代理机构： Ebner von Eschenbach, Jennifer
- 优先权： US156868P 19990930
- 国际公布： WO0123388 20010405
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519 ; A61K31/53 ; A61P9/00 ; A61P25/00 ; G01N33/566
摘要：
Disclosed are compounds of the formula: (I), where R?1, R2, R3, R4, R5, R6¿, and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the treatment of a number of CNS disorders, metabolic disorders, and peripheral disorders, particularly eating disorders and hypertension. Methods of treatment of such disorders as well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of NPY1 receptors and as standards in assays for NPY1 receptor binding. Methods of using the compounds in receptor localization studies are given.
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