发明公开
EP1223215A1 TRANSFORMANT PRODUCING SECONDARY METABOLITE MODIFIED WITH FUNCTIONAL GROUP AND NOVEL BIOSYNTHESIS GENES
审中-公开
TRANSFORM ANTE其与改性的次级代谢产物MAKING的官能团，以及新的生物合成基因
- 专利标题： TRANSFORMANT PRODUCING SECONDARY METABOLITE MODIFIED WITH FUNCTIONAL GROUP AND NOVEL BIOSYNTHESIS GENES
- 专利标题（中）： TRANSFORM ANTE其与改性的次级代谢产物MAKING的官能团，以及新的生物合成基因
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申请号： EP00962989.0申请日： 2000-09-29
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公开(公告)号： EP1223215A1公开(公告)日： 2002-07-17
- 发明人: YANAI, Koji Pharmaceutical Technology Labs. , OKAKURA, Kaoru Pharmaceutical Technology Labs. , YASUDA, Shohei Pharmaceutical Technology Labs. , WATANABE, Manabu Pharmaceutical Technology Labs. , MIYAMOTO, Koichi Pharmaceutical Technology Labs. , MIDOH, Naoki Pharmaceutical Technology Labs. , MURAKAMI, Takeshi Pharmaceutical Technology Labs.
- 申请人： Meiji Seika Kaisha, Ltd.
- 申请人地址： 4-16, Kyobashi 2-chome, Chuo-ku Tokyo 104-8002 JP
- 专利权人： Meiji Seika Kaisha, Ltd.
- 当前专利权人： Meiji Seika Kaisha, Ltd.
- 当前专利权人地址： 4-16, Kyobashi 2-chome, Chuo-ku Tokyo 104-8002 JP
- 代理机构： Hall, Marina
- 优先权： JP27631499 19990929
- 国际公布： WO0123542 20010405
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; C12N5/10 ; C12P21/02 ; C07K11/00
摘要：
An objective of the present invention is to provide a transformant altered so as to produce a secondary metabolite in which a benzene ring of the secondary product is modified at the para-position with a functional group containing a nitrogen atom. A transformant according to the present invention is a transformant of an organism producing a secondary metabolite having a benzene ring skeleton without substitution at the para-position with a functional group containing a nitrogen atom, said transformant being transformed by introducing a gene involved in a biosynthetic pathway from chorismic acid to p -aminophenylpyruvic acid so as to produce a secondary metabolite having a benzene ring skeleton substituted at the para-position with a functional group containing a nitrogen atom. Another objective of the present invention is to provide a novel gene involved in the biosynthetic pathway from chorismic acid to p -aminophenylpyruvic acid. A novel gene according to the present invention comprises genes encoding the amino acid sequences of SEQ ID NOs: 2, 4 and 6 or modified sequences thereof.
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