公开(公告)号：EP3838914A1

公开(公告)日：2021-06-23

申请号：EP20212853.4

申请日：2016-03-23

申请人： Bayer CropScience LP

发明人： BEAU, Jeremy ,  JOO, Daniel ,  SCHWIENTEK, Patrick ,  TAYLOR, Colleen ,  TRAAG, Bjorn

IPC分类号： C07K11/02 ,  C07K11/00 ,  A01N63/00 ,  A01N63/10

摘要： The present invention relates to a composition comprising a biologically pure culture of a fungicidal Paenibacillus sp. strain comprising a variant fusaricidin synthetase lacking a functional adenylation domain in the third module. The present invention also provides a composition comprising a biologically pure culture of a fungicidal Paenibacillus sp. strain or a cell-free extract thereof comprising at least one Paeniserine and at least one Paeniprolixin. Also provided are isolated compounds and methods of treating a plant to control a plant disease with the disclosed compositions and compounds.

公开(公告)号：EP3383418A1

公开(公告)日：2018-10-10

申请号：EP16871668.6

申请日：2016-12-02

申请人： Board of Regents, The University of Texas System

发明人： LIZEE, Gregory ,  YEE, Cassian ,  HWU, Patrick ,  ROSZIK, Janos

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61P35/00 ,  C07K11/00 ,  C07K14/435

CPC分类号： A61K39/0011 ,  A61K9/0019 ,  A61K9/0043 ,  A61K35/17 ,  A61K38/00 ,  A61K45/06 ,  A61P35/00 ,  C07K14/70539

摘要： Provided are SLC45A2 peptides that bind to MHC I (HLA-A2) on melanoma cells or other antigen-presenting cells and are recognized by T-cell receptors on T cells. The SLC45 A2 peptides may be therapeutically used to treat a cancer, such as a cutaneous melanoma, uveal melanoma, a mucosal melanoma, or a metastatic melanoma. Methods for expanding a population of T cells that target SLC45A2 are also provided.

公开(公告)号：EP2445873B1

公开(公告)日：2014-12-17

申请号：EP10792775.8

申请日：2010-06-26

申请人： University of Florida Research Foundation, Inc.

发明人： LUESCH, Hendrik ,  PAUL, Valerie, J. ,  KWAN, Jason, C.

IPC分类号： C07D207/10 ,  A61K31/40 ,  A61P25/28 ,  C07K11/00

CPC分类号： C07K11/00 ,  A61K38/00

公开(公告)号：EP2552470A4

公开(公告)日：2014-02-19

申请号：EP11759758

申请日：2011-03-25

申请人： INDUSTRY ACADEMIC COOPERATION FOUNDATION SOOKMYUNNG WOMEN S UNIVERSITY ,  IL YANG PHARM CO LTD ,  SAMSUNG LIFE WELFARE FOUND

发明人： CHO DAE HO ,  BANG SA IK ,  PARK JEONG MIN ,  YOON SUN YOUNG ,  KIM SANG YOON ,  LEE HA RUM ,  PARK YOO RIM ,  SON JUAH

IPC分类号： A61K38/08 ,  A61K38/00 ,  A61K38/07 ,  A61P9/00 ,  A61P17/02 ,  C07K5/10 ,  C07K7/06 ,  C07K11/00

CPC分类号： A61K38/08 ,  A61K38/00 ,  A61K38/07 ,  C07K5/10 ,  C07K5/101 ,  C07K7/06 ,  C07K2319/00 ,  C07K2319/50

摘要： The present invention relates to a peptide promoting angiogenesis and novel use thereof. More particularly, the invention relates to peptides promoting angiogenesis, and the use of the peptide for promoting angiogenesis and preventing or treating angiogenesis-related disease. The peptide of the present invention have an excellent effect on prompting angiogenesis. Accordingly, it is useful for preventing or treating angiogenesis-related disease and for preparing regeneration of skin flap, wound and burn healing, implantation of artificial skin and preparation of blood vessels for transplantation.

公开(公告)号：EP2448956A1

公开(公告)日：2012-05-09

申请号：EP10726518.3

申请日：2010-06-29

申请人： Centre National de la Recherche Scientifique CNRS

发明人： CAUSSIL-AMBLARD, Muriel ,  MARTINEZ, Jean ,  TAILHADES, Julien

IPC分类号： C07K1/04 ,  C07K7/06 ,  C07K7/28 ,  C07K11/00

CPC分类号： C07K1/04 ,  C07K1/06 ,  C07K1/061 ,  C07K1/062 ,  C07K1/063 ,  C07K2/00 ,  C07K7/02 ,  C07K7/28 ,  C07K14/6555

摘要： The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O-N acyl shift enabling to obtain the corresponding peptide alcohols.

公开(公告)号：EP2121731A1

公开(公告)日：2009-11-25

申请号：EP08710443.6

申请日：2008-02-21

申请人： Oncotherapy Science, Inc.

发明人： TSUNODA, Takuya ,  OHSAWA, Ryuji

IPC分类号： C07K14/00 ,  A61K38/00 ,  A61P35/00 ,  C07K11/00 ,  C12N5/10 ,  G01N33/15 ,  G01N33/50

CPC分类号： C07K14/47 ,  A61K39/0011 ,  A61K2039/55555 ,  C07K14/4748

摘要： The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: SEQ ID NO: 19, 22, 30, 34, 344, 358, 41, 44, 46, 48, 78, 376, 379, 80, 100, 101, 110, 111, 387, 112, 394, 114, 116, 117, 121, 395, 133, 135, 137, 426, 174, 178, 186, 194, 196, 202, 210, 213, 214, 217, 223, 227, 228, 233, 254, 271, 272 or 288, as well as peptides having the above-mentioned amino acid sequences in which 1, 2, or several (e.g., up to 5) amino acids are substituted, deleted, or added, provided the peptides possess cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing a disease associated with over-expression of the CDH3, EPHA4, ECT2, HIG2, INHBB, KIF20A, KNTC2, TTK and/or URLC10, e.g. cancers containing as an active ingredient one or more of these peptides. The peptides of the present invention find further utility as vaccines.

公开(公告)号：EP2089416A1

公开(公告)日：2009-08-19

申请号：EP07848705.5

申请日：2007-11-23

申请人： UNIVERSITY OF SOUTHAMPTON

发明人： PACKHAM, Graham Keith ,  GANESAN, Arasu ,  CECIL, Alexander Richard Liam

IPC分类号： C07K5/02 ,  C07K11/00 ,  A61P9/00 ,  A61P25/00 ,  A61P35/00 ,  A61K38/06 ,  A61K38/15

CPC分类号： C07K5/0205

摘要： Compounds which are Spiruchostatin analogues of the general formula (I) or (I'), isosteres thereof and pharmaceutically acceptable salts thereof are found to inhibit HDAC wherein R1, R2, R3 and R4 are the same or different and represent an amino acid side chain moiety and each R6 is the same or different and represents hydrogen or C1-C4 alkyl.

公开(公告)号：EP1468014B1

公开(公告)日：2009-04-22

申请号：EP02797061.5

申请日：2002-10-30

申请人： CORIXA CORPORATION

发明人： GAIGER, Alexander ,  MCNEILL, Patricia, D. ,  JAYA, Nomalie ,  CARTER, Darrick

IPC分类号： C07K14/00 ,  C07K11/00 ,  C07K7/00 ,  A61K48/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/515 ,  C07K2319/00

公开(公告)号：EP1806377A4

公开(公告)日：2008-04-23

申请号：EP05795884

申请日：2005-10-20

申请人： UNIV GUNMA NAT UNIV CORP

发明人： OKU HIROYUKI ,  SHICHIRI KAZUAKI ,  TAIRA TOMOHIRO ,  INOUE AYA ,  YAMADA KEIICHI ,  KATAKAI RYOICHI

IPC分类号： C08G63/06 ,  A61K47/42 ,  C07K11/00 ,  C07K14/00 ,  C08G69/44

CPC分类号： C08G63/6852 ,  A61K47/42 ,  C07K11/00

摘要： There is provided a temperature responsive polymer compound which comprises a repeating unit represented by the following general formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ-R 1 -Hmb-R 2 -€ƒ€ƒ€ƒ€ƒ€ƒ(I) where, Hmb represents a valic acid residue represented by the following formula (II); R 1 represents an amino acid, a polypeptide, or a hydroxy acid being linked by ester bond; R 2 represents an amino acid or a polypeptide being linked by amide bond or a hydroxy acid being linked by ester bond: and wherein said polymer compound has 18 or more of amino acids residues and hydroxy acid residues in total.

摘要翻译： 具有下述通式（I）所示的重复单元的温度响应性聚合物：-R

公开(公告)号：EP1795538A1

公开(公告)日：2007-06-13

申请号：EP06122212.1

申请日：2003-07-01

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： Butz, Karin ,  Crnkovic-Mertens, Irena ,  Hope-Seyler, Felix ,  Rausch, Christian

IPC分类号： C07K11/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K14/001 ,  C07K14/4747

摘要： The present invention relates to peptides which interact with IAPs. IAPs are highly expressed in tumor cells which fail to undergo apoptosis. By binding to IAPs, the peptides of the present invention release tumor cells from the apoptosis block and thus provide a new tool for effective cancer therapy.

摘要翻译： 本发明涉及与IAP相互作用的肽。 IAP在不能进行细胞凋亡的肿瘤细胞中高度表达。 通过结合IAP，本发明的肽从凋亡阻断区释放肿瘤细胞，从而提供有效的癌症治疗的新工具。