发明公开
EP1224240A1 8-(ANILINO)-1-NAPHTHALENESULFONATE ANALOGS AND THEIR USE IN ANALYTE DETECTION ASSAYS
有权
8-(苯胺基)-1-萘磺酸酯类似物及其在分析检测中的应用
- 专利标题: 8-(ANILINO)-1-NAPHTHALENESULFONATE ANALOGS AND THEIR USE IN ANALYTE DETECTION ASSAYS
- 专利标题(中): 8-(苯胺基)-1-萘磺酸酯类似物及其在分析检测中的应用
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申请号: EP00973725.5申请日: 2000-10-17
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公开(公告)号: EP1224240A1公开(公告)日: 2002-07-24
- 发明人: ZHENG, Xiaoling , YU, Yeung, Siu , YANI, Adva , HUANG, Paing, C.
- 申请人: Lifescan, Inc.
- 申请人地址: 1000 Gibraltar Drive Milpitas,California 95035-6312 US
- 专利权人: Lifescan, Inc.
- 当前专利权人: Lifescan, Inc.
- 当前专利权人地址: 1000 Gibraltar Drive Milpitas,California 95035-6312 US
- 代理机构: Mercer, Christopher Paul
- 优先权: US428296 19991027
- 国际公布: WO0130915 20010503
- 主分类号: C09B27/00
- IPC分类号: C09B27/00 ; C07C309/47 ; C12Q1/28 ; C12Q1/54
摘要:
8-(anilino)-1-naphthalenesulfonate (ANS) analogs and methods for their use in analyte detection assays are provided. The subject ANS analogs are characterized by having at least one non-hydrogen substituent on their phenyl moiety and producing a reaction product with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) or an analog thereof, e.g. MBTHSB, that exhibits reduced drift. In certain preferred embodiments, the subject ANS analogs are described by formula (I) wherein: n is 1 to 5; and X is a substituent other than H. The subject ANS analogs find use in a variety of applications, particularly in analyte detection assays, such as glucose detection assays.
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