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公开(公告)号：EP4426852A1
公开(公告)日：2024-09-11
申请号：EP22890508.9
申请日：2022-11-04
IPC分类号： C12Q1/04 , C12Q1/28 , G01N21/25 , G01N33/569 , G01N33/53 , G01N33/543
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公开(公告)号：EP4417701A1
公开(公告)日：2024-08-21
申请号：EP22717334.1
申请日：2022-02-24
申请人： Daan Gene Co., Ltd.
发明人： JIANG, Xiwen , QI, Wenchuang , WU, Runfeng , DUAN, Shaoqing , JIAN, Junxing , DIAO, Xue
摘要： The embodiments of the present application, belonging to the technical field of medical test and assay, and provide a preservative for an in vitro diagnostic reagent. The preservative includes a combination of a sulfadoxine solution and a dimethoprim solution, wherein a molar ratio of sulfadoxine in the sulfadoxine solution to dimethoprim in the dimethoprim solution is from 0.002 to 1. The present disclosure also provides use of the preservative for the in vitro diagnostic reagent. The technical solutions according to the embodiments of the present disclosure improve stability of the reagent, do not affect reactions of the reagent, and may be extensively applied.
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公开(公告)号：EP4239077A2
公开(公告)日：2023-09-06
申请号：EP23169604.8
申请日：2021-03-19
申请人： Belgian Volition SRL
IPC分类号： C12Q1/28 , G01N33/569 , G01N33/68
摘要： The invention relates to using cell free nucleosome levels to identify patients at risk of developing a NETosis associated adverse reaction to the infection. The methods are used to monitor the progress of a disease and assigning a risk of an adverse outcome in a patient suffering from an infection.
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公开(公告)号：EP4220164A2
公开(公告)日：2023-08-02
申请号：EP23157811.3
申请日：2017-12-18
IPC分类号： G01N33/542 , G01N33/543 , G01N33/58 , C12Q1/28
摘要： Methods and systems are provided for quantitative immunohistochemistry (IHC) of a target protein molecule including a secreted target protein molecule. The method comprises introducing to the sample: a primary antibody specific for the target protein molecule; a secondary antibody conjugated to a secondary antibody enzyme, the secondary antibody is specific for the primary antibody; a tyramide conjugated with a tyramide hapten, wherein the secondary antibody enzyme catalyzes deposition of the tyramide hapten onto the sample; a tertiary antibody conjugated with a tertiary antibody enzyme, the tertiary antibody is specific for the tyramide hapten; and a chromogen, wherein the tertiary antibody enzyme catalyzes a reaction with the chromogen to make the chromogen visible. The chromogen is visible as a punctate dot using microscopy.
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公开(公告)号：EP4212627A1
公开(公告)日：2023-07-19
申请号：EP21866847.3
申请日：2021-09-10
摘要： An object of the present invention is to provide a method for measuring an object to be measured in a specimen by an enzymatic method, the measurement method being able to suppress the positive influence of peroxide derived from the specimen. More specifically, an object of the present invention is to provide a measurement method and a measurement reagent that can suppress elevation in value regardless of whether or not the specimen is a catalase-free specimen. Provided is a measurement method that can accurately quantify hydrogen peroxide derived from an object to be measured, without influence derived from a specimen, by contacting the specimen with an enzyme in the presence of at least one compound selected from the group consisting of a compound represented by the following general formula (I), a benzimidazole derivative having an electron-donating substituent at position 2, and histidine, wherein R1 and R2 are the same or different and each represent hydrogen, a linear or branched alkyl group having 1 to 6 carbon atoms and optionally having a substituent, an aryl group optionally having a substituent, or an alkyloxy group having 1 to 6 carbon atoms.
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公开(公告)号：EP4159852A1
公开(公告)日：2023-04-05
申请号：EP21818719.3
申请日：2021-06-02
发明人： ITOH Yasuki
摘要： There is provided a kit that is used for fractionation of cholesterol (lipoprotein C) in a lipoprotein other than small dense LDL in a sample, the kit containing a first reagent composition having at least one activity selected from the group consisting of a cholesterol esterase activity and a cholesterol oxidase activity and a second reagent composition for quantifying the lipoprotein C of a measurement target, where a ratio R1 represented by ABS400/ABS450 is 0.90 or more and 3.50 or less, and in an absorption spectrum after storing the second reagent composition at 37°C for two weeks, the ratio R1 represented by ABS400/ABS450 is 0.90 or more and 9.00 or less.
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公开(公告)号：EP4130288A1
公开(公告)日：2023-02-08
申请号：EP21782016.6
申请日：2021-04-01
摘要： A staining method includes staining a biological sample with a coumarin fluorescent dye to provide a fluorescent-stained sample, and bringing the fluorescent-stained sample into contact with osmium tetroxide, further embedding the sample in an epoxy resin, and subsequently slicing the sample to provide a section sample including the fluorescent-stained sample.
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公开(公告)号：EP4121551A1
公开(公告)日：2023-01-25
申请号：EP21714838.6
申请日：2021-03-19
申请人： Belgian Volition SRL
IPC分类号： C12Q1/28 , G01N33/569 , G01N33/68
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公开(公告)号：EP4031658A1
公开(公告)日：2022-07-27
申请号：EP20763991.5
申请日：2020-08-07
申请人： DB Biotech, AS
IPC分类号： C12N9/08 , G01N33/58 , C12Q1/28 , G01N33/535
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公开(公告)号：EP4029948A1
公开(公告)日：2022-07-20
申请号：EP20862190.4
申请日：2020-09-09
发明人： ITOH, Yasuki , SATOH, Noriyuki
摘要： This invention provides a method for quantifying cholesterol in small, dense LDL in two steps using an autoanalyzer without pretreatment of an analyte, wherein spontaneous color development of a reagent during storage is suppressed, a kit for quantification used in the method, and a method for preparing such kit. The kit for quantification of cholesterol in small, dense LDL in a sample obtained from a subject used in the method for quantifying cholesterol in small, dense LDL in two steps comprises: (1) a first reagent composition having cholesterol esterase activity, cholesterol oxidase activity, and sphingomyelinase activity and leading cholesterol in lipoproteins other than small, dense LDL to the outside of the reaction system in the presence of cholesterol esterase activity, cholesterol oxidase activity, and sphingomyelinase activity; and (2) a second reagent composition for quantifying cholesterol in small, dense LDL, wherein a coupler, an iron complex, and peroxidase activity are not allowed to be present in the same reagent composition, which is either the first reagent composition or the second reagent composition.
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