发明公开
EP1225955A1 ARYL OLEFINIC AZACYCLIC, AND ARYL ACETYLENIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS
审中-公开
芳基烯烃氮杂环，和芳基乙炔化合物氮杂含药物制剂及其使用尼古丁胆碱能受体的抑制剂
- 专利标题： ARYL OLEFINIC AZACYCLIC, AND ARYL ACETYLENIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS
- 专利标题（中）： 芳基烯烃氮杂环，和芳基乙炔化合物氮杂含药物制剂及其使用尼古丁胆碱能受体的抑制剂
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申请号： EP00948568.1申请日： 2000-06-30
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公开(公告)号： EP1225955A1公开(公告)日： 2002-07-31
- 发明人: SCHMITT, Jeffrey, Daniel , DULL, Gary, Maurice , BHATTI, Balwinder, Singh
- 申请人： Targacept, Inc.
- 申请人地址： P.O. Box 1487 Winston-Salem, NC 27102-1487 US
- 专利权人： Targacept, Inc.
- 当前专利权人： Targacept, Inc.
- 当前专利权人地址： P.O. Box 1487 Winston-Salem, NC 27102-1487 US
- 代理机构： Bassett, Richard Simon
- 优先权： US431700 19991101
- 国际公布： WO0132264 20010510
- 主分类号： A61P25/00
- IPC分类号： A61P25/00 ; A61K31/4406 ; C07D453/02 ; C07D213/32 ; C07D401/06 ; C07D487/04 ; C07D209/02
摘要：
Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryl olefinic azacyclic compounds and aryl acetylenic azacylic compounds, including pyridyl olefinic cycloalkylamines and pyridyl acetylenic cycloalkylamines. Exemplary compounds include (S)-(E)-3-(3-pyrrolidin-2-yl-prop-1-enyl)pyridine, (S)-(E)-3-(2-pyrrolidin-2-ylvinyl)pyridine, 3-(2-pyrrolidin-2-ylethenyl)pyridine, 3-(3-pyrrolidin-2-ylprop-1-enyl)pyridine, 3-(2-(2-azetidinyl)ethenyl)pyridine, 3-(3-(2-azetidinyl) prop-1-enyl)pyridine, 2-(2-(3-pyridyl)ethenyl)-1-azabicyclo[3.3.0]octane, 2-(3-(3-pyridyl)prop-2-enyl)-1-azabicyclo[3.3.0]octane, 3-(2-(3-pyridyl)ethenyl)-2-azabicyclo[2.2.1]heptane, 3-(3-(3-pyridyl)prop-2-enyl)-2-azabicyclo[2.2.1]heptane, 2-(2-(3-pyridyl)ethenyl)-7-azabicyclo[2.2.1]heptane, 2-(3-(3-pyridyl)prop-2-enyl)-7-azabicyclo[2.2.1]heptane, 2-(2-(3-pyridyl)ethenyl)quinuclidine and 2-(3-(3-pyridyl)prop-2-enyl)quinuclidine.
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