发明公开
- 专利标题: DRUG DISCHARGE PUMP INHIBITORS
- 专利标题(中): PUMPENINHIBITOREN ZUR FREISETZUNG VON MEDIKAMENTEN
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申请号: EP00970155申请日: 2000-10-27
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公开(公告)号: EP1227084A4公开(公告)日: 2003-08-20
- 发明人: LEGER ROGER , WATKINS WILLIAM JOHN , ZHANG JASON ZHIJIA , RENAU THOMAS ERIC , LEE VING JACK , OHTA TOSHIHARU , NAKAYAMA KIYOSHI , ISHIDA YOHHEI , OHTSUKA MASAMI , KAWATO HARUKO
- 申请人: ESSENTIAL THERAPEUTICS INC , DAIICHI SEIYAKU CO
- 专利权人: ESSENTIAL THERAPEUTICS INC,DAIICHI SEIYAKU CO
- 当前专利权人: ESSENTIAL THERAPEUTICS INC,DAIICHI SEIYAKU CO
- 优先权: JP2000326713 2000-10-26; US42846699 1999-10-28
- 主分类号: A61K31/341
- IPC分类号: A61K31/341 ; A61K31/41 ; A61K31/421 ; A61K31/423 ; A61K31/426 ; A61K31/427 ; A61K31/433 ; A61K31/437 ; A61K31/4375 ; A61K31/44 ; A61K31/4439 ; A61K31/47 ; A61K31/4709 ; A61K31/4738 ; A61K31/502 ; A61K31/517 ; A61K31/519 ; A61K31/5383 ; A61P31/04 ; C07D277/26 ; C07D277/28 ; C07D277/32 ; C07D277/44 ; C12Q1/18 ; G01N33/68 ; C07D213/30 ; A61K31/425 ; C07D215/14 ; C07D215/56 ; C07D263/56 ; C07D307/52 ; C07D513/04
摘要:
Drugs for preventing and/or treating microbial infectious diseases which contain, as the active ingredient, compounds represented by the formula (I), physiologically acceptable salts thereof or hydrates of the same and have an effect of making a microorganism having acquired tolerance to a drug non-tolerant. In said formula R?1 and R2¿ independently represent each hydrogen, halogeno, carboxy, etc.; J1 represents 5- or 6-membered heteroaryl; W1 represents -CH=CH-, -CH CH-, -CH¿2?CH2-, etc.; A?1¿ represents phenylene, pyridinedyl, furandyl, etc.; G1 represents oxygen, carbonyl, ethynyl, etc.; p is an integer of from 0 to 3; G2 represents phenylene, furandyl, tetrahydrofurandyl, etc.; G3 represents -CH¿2?- or a single bond; m and n represent each an integer of 0 or 1; and Q?1¿ represents an acidic group.
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