发明公开
- 专利标题： METHODS FOR INHIBITING NEUROFIBROMATOSIS TYPE 1 (NF1)
- 专利标题（中）： 于抑制神经纤维瘤第一型方法（NF1）
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申请号： EP00975626.3申请日： 2000-11-10
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公开(公告)号： EP1227846A2公开(公告)日： 2002-08-07
- 发明人: CLAPP, Wade, D. , INGRAM, David, A. , MARSHALL, Mark, Steven
- 申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc. , Clapp, Wade D. , Ingram, David A. , Marshall, Mark Steven
- 申请人地址： Suite 100,1100 Waterway Boulevard Indianapolis, IN 46202 US
- 专利权人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.,Clapp, Wade D.,Ingram, David A.,Marshall, Mark Steven
- 当前专利权人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc.,Clapp, Wade D.,Ingram, David A.,Marshall, Mark Steven
- 当前专利权人地址： Suite 100,1100 Waterway Boulevard Indianapolis, IN 46202 US
- 代理机构： Wiklund, Erik
- 优先权： US165218P 19991112
- 国际公布： WO0134201 20010517
- 主分类号： A61K45/00
- IPC分类号： A61K45/00
摘要：
A method is provided to identify inhibitors of any one of Raf, MEK, extracellular signal regulated kinase 1 (ERK1), extracellular signal regulated kinase 2 (ERK2), phosphatidylinositol triphosphate kinase (PI3K), p21 activated kinase 2 (PAK2), p21 activated kinase 3 (PAK3), Rac, CDC42, p21 activated kinase 1 (PAK1), protein kinase B (PKB), Akt, and c-jun N-terminal kinase (JNK), or crosstalk between the PI3-K an the Ras-Raf-MEK-ERK pathway, useful to treat disorders such as neurofibromatosis type 1 or at least one clinical manifestation thereof.
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