发明公开
EP1241598A4 METHOD AND DEVICE FOR CALCULATING OPTIMIZATION SOLUTION OF MULTIPLE MUTANT PROTEIN AMINO ACID SEQUENCE, AND STORAGE MEDIUM WHERE PROGRAM FOR EXECUTING THE METHOD IS STORED
审中-公开
方法和设备计算几种突变蛋白和存储介质的氨基序列的优化解决方案，用于存储有关方案
- 专利标题： METHOD AND DEVICE FOR CALCULATING OPTIMIZATION SOLUTION OF MULTIPLE MUTANT PROTEIN AMINO ACID SEQUENCE, AND STORAGE MEDIUM WHERE PROGRAM FOR EXECUTING THE METHOD IS STORED
- 专利标题（中）： 方法和设备计算几种突变蛋白和存储介质的氨基序列的优化解决方案，用于存储有关方案
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申请号： EP00987705申请日： 2000-12-21
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公开(公告)号： EP1241598A4公开(公告)日： 2006-07-26
- 发明人: MORIKAWA SOUICHI , NAKAI TAKAHISA , ISHII KIYOTO
- 申请人： KANEKA CORP
- 专利权人： KANEKA CORP
- 当前专利权人： KANEKA CORP
- 优先权： JP36849899 1999-12-24; US17764602 2002-06-20
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; C07K14/00 ; G06F17/30 ; G06F17/50 ; G06F19/00 ; G06F19/16
摘要：
A method for calculating the solution of optimization of a multiple mutant protein amino acid sequence, comprises a step of seeking the amino acid side chain three-dimensional structure coordinates of the amino acid sequence of each of the members of a multiple mutant protein group on the basis of the three-dimensional structure data on a template protein group according to a dead end elimination algorithm and calculating the minimization of the structure energy of the member to calculate the optimum three-dimensional coordinates of the multiple mutant protein, a step calculating the characteristic value from the optimum three-dimensional structure coordinates, and a step of calculating the member that optimizes the characteristic value by applying a genetic algorithm to the multiple mutant protein group. From the multiple mutant protein group including a vast number of combinations, the solution of optimization is selected on the basis of the characteristic value in a short time without degrading the accuracy.
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