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    STEREOSTRUCTURE OF DECARBAMYLASE AND METHOD OF USING THE SAME
    1.
    发明公开
    STEREOSTRUCTURE OF DECARBAMYLASE AND METHOD OF USING THE SAME 审中-公开
    FOR USE脱和方法的立体结构

    公开(公告)号：EP1209234A4

    公开(公告)日：2003-05-02

    申请号：EP00956828

    申请日：2000-08-30

    申请人： KANEKA CORP

    发明人： NAKAI TAKAHISA ,  MORIKAWA SOUICHI ,  ISHII KIYOTO ,  NANBA HIROKAZU ,  YAJIMA KAZUYOSHI ,  IKENAKA YASUHIRO ,  TAKAHASHI SATOMI

    IPC分类号： C12N15/09 ,  C12N9/80 ,  C12N9/88 ,  C12N15/60 ,  G06F17/30

    CPC分类号： C12N9/80

    摘要： Excellent decarbamylase variants which are more advantageously usable industrially are provided by clarifying the stereostructure of decarbamylase by X-ray crystalline structure analysis and designing molecules aiming at elevating the reactivity to the substrates (D-N-carbamoyl- alpha -amino acids), etc. by using the stereostructure. More particularly speaking, provision is made of: the stereostructure of decarbamylase determined by X-ray crystalline structure analysis, stereostructure models of variants thereof and stereostructure models of complexes thereof with substrates, products, etc.; a molecular design method with the use of these stereostructures; a method of obtaining decarbamylase variants by using this method; the decarbamylase variants obtained by this method; and a method of designing and producing variants of proteins which are similar to decarbamylase in structure.

    PEPTIDE CAPABLE OF BINDING TO INSULIN-BINDING PROTEIN AND ADSORBENT
    2.
    发明公开
    PEPTIDE CAPABLE OF BINDING TO INSULIN-BINDING PROTEIN AND ADSORBENT 有权
    结合胰岛素结合蛋白肽CAPABLE与吸附剂

    公开(公告)号：EP1790654A4

    公开(公告)日：2008-01-09

    申请号：EP05770543

    申请日：2005-08-09

    申请人： KANEKA CORP

    发明人： YONEZAWA AI ,  MORIKAWA SOUICHI ,  OGINO EIJI

    IPC分类号： C07K14/62 ,  A61K47/48 ,  C07K7/00 ,  C12M1/00

    CPC分类号： C07K14/62 ,  A61K47/585 ,  A61K47/6957 ,  C07K7/06

    摘要： It is intended to provide a peptide having an excellent ability to bind to a protein capable of binding to insulin (IBP); an adsorbent comprising this peptide fixed on a water-insoluble support; an adsorption apparatus containing this adsorbent; and a method of adsorbing IBP with the use of the above adsorbent or adsorption apparatus. By using the above-described peptide, adsorbent, adsorption apparatus and method, IBP can be efficiently and selectively adsorbed and removed. Thus, they are usable in, for example, treating diseases on which IBP acts as a worsening factor such as diabetes.

    METHOD OF MODIFYING ENZYME AND OXIDOREDUCTASE VARIANT
    3.
    发明公开
    METHOD OF MODIFYING ENZYME AND OXIDOREDUCTASE VARIANT 审中-公开
    内切酶修饰酶和氧化还原酶VARIANT方法

    公开(公告)号：EP1416050A4

    公开(公告)日：2004-12-22

    申请号：EP02738904

    申请日：2002-07-02

    申请人： KANEKA CORP

    发明人： NAKAI TAKAHISA ,  MORIKAWA SOUICHI ,  KIZAKI NORIYUKI ,  YASOHARA YOSHIHIKO

    IPC分类号： C12N1/21 ,  C12N9/04 ,  C12N9/06 ,  C12N15/53 ,  C12P7/62

    CPC分类号： C12N9/0006 ,  C12P7/62

    摘要： A method of modifying an enzyme whereby the coenzyme-dependency of an oxidoreductase is changed is developed. Using this method, a novel carbonyl reductase variant capable of using NADH as a coenzyme is provided. It is also intended to provide a process of enzymatically producing an optically active (S)-4-halo-3-hydroxybutyric acid ester by using the carbonyl reductase variant. A method of modifying an enzyme itself so as to change the coenzyme-dependency of carbonyl reductase which asymmetrically reduce a carbonyl compound to give an optically active alcohol; a carbonyl reductase having been converted in the coenzyme-dependency from NADPH to NADH which is obtained by the above method; DNA encoding this enzyme variant; a plasmid having this DNA; transformant cells transformed by this plasmid; and a process for producing an optically active alcohol by using the above enzyme variant and/or the above transformed cells.

    HEAT SHOCK FACTOR ACTIVITY INHIBITORS
    4.
    发明公开
    HEAT SHOCK FACTOR ACTIVITY INHIBITORS 失效
    热休克因子的抑制剂

    公开(公告)号：EP0995745A4

    公开(公告)日：2002-11-06

    申请号：EP98929672

    申请日：1998-06-25

    申请人： KANEKA CORP

    发明人： YOKOTA SHIN-ICHI ,  YAMAMOTO KOZO ,  MORIKAWA SOUICHI ,  FUSE YOSHIHIDE ,  KITAHARA MIKIO

    IPC分类号： C07D405/06 ,  A61K31/40 ,  A61K31/445

    CPC分类号： C07D405/06

    摘要： Remedies for diseases which function by regulating the expression of a protein induced by a heat shock factor (HSF). Specifically, HSF activity inhibitors or agents inhibiting the induction of the production of a protein regulated by HSF, wherein novel benzo-1,3-dioxole compounds represented by general formula (I) inhibit the transcription of a structural gene having a heat shock element sequence, which is a transcriptional regulatory factor, in a gene region participating in the transcription into RNA, thus inhibit the translation of this gene into a protein and, in its turn, suppress the induction of the production of the RNA, protein, etc. encoded by the gene; and remedies and preventives usable in thermotherapy for cancer and remedies and preventives for stress-induced diseases such as depression. Compounds represented by general formula (I): wherein X is -CH2- and R1 represents C¿1-2? alkyl, formyl or halogeno; or X is -(CH2)2- and R?1¿ represents C¿1-3? alkyl, formyl, acetyl, hydrogen or halogeno.

    METHOD AND DEVICE FOR CALCULATING OPTIMIZATION SOLUTION OF MULTIPLE MUTANT PROTEIN AMINO ACID SEQUENCE, AND STORAGE MEDIUM WHERE PROGRAM FOR EXECUTING THE METHOD IS STORED
    6.
    发明公开
    METHOD AND DEVICE FOR CALCULATING OPTIMIZATION SOLUTION OF MULTIPLE MUTANT PROTEIN AMINO ACID SEQUENCE, AND STORAGE MEDIUM WHERE PROGRAM FOR EXECUTING THE METHOD IS STORED 审中-公开
    方法和设备计算几种突变蛋白和存储介质的氨基序列的优化解决方案，用于存储有关方案

    公开(公告)号：EP1241598A4

    公开(公告)日：2006-07-26

    申请号：EP00987705

    申请日：2000-12-21

    申请人： KANEKA CORP

    发明人： MORIKAWA SOUICHI ,  NAKAI TAKAHISA ,  ISHII KIYOTO

    IPC分类号： C12N15/09 ,  C07K14/00 ,  G06F17/30 ,  G06F17/50 ,  G06F19/00 ,  G06F19/16

    CPC分类号： G06F19/16 ,  G06F19/18

    摘要： A method for calculating the solution of optimization of a multiple mutant protein amino acid sequence, comprises a step of seeking the amino acid side chain three-dimensional structure coordinates of the amino acid sequence of each of the members of a multiple mutant protein group on the basis of the three-dimensional structure data on a template protein group according to a dead end elimination algorithm and calculating the minimization of the structure energy of the member to calculate the optimum three-dimensional coordinates of the multiple mutant protein, a step calculating the characteristic value from the optimum three-dimensional structure coordinates, and a step of calculating the member that optimizes the characteristic value by applying a genetic algorithm to the multiple mutant protein group. From the multiple mutant protein group including a vast number of combinations, the solution of optimization is selected on the basis of the characteristic value in a short time without degrading the accuracy.