发明公开
EP1242432A1 PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B)
审中-公开
膦酸衍生物作为蛋白酪氨酸磷酸酶1B（PTP-1B）抑制剂
- 专利标题： PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B)
- 专利标题（中）： 膦酸衍生物作为蛋白酪氨酸磷酸酶1B（PTP-1B）抑制剂
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申请号： EP00986934.8申请日： 2000-12-21
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公开(公告)号： EP1242432A1公开(公告)日： 2002-09-25
- 发明人: LEBLANC, Yves , LAU, Cheuk, Kun , DUFRESNE, Claude , LI, Chun, Sing , ROY, Patrick , WANG, Zhaoyin , SCHEIGETZ, John , BOYD, Michael
- 申请人： MERCK FROSST CANADA INC.
- 申请人地址： 16711 Trans-Canada Highway KirklandQuebec H9H 3L1 CA
- 专利权人： MERCK FROSST CANADA INC.
- 当前专利权人： MERCK FROSST CANADA INC.
- 当前专利权人地址： 16711 Trans-Canada Highway KirklandQuebec H9H 3L1 CA
- 代理机构： Thompson, John Dr.
- 优先权： US171426P 19991222
- 国际公布： WO01046205 20010628
- 主分类号： C07F9/38
- IPC分类号： C07F9/38 ; C07F9/6518 ; C07F9/58 ; C07F9/653 ; C07F9/40 ; A61K31/66 ; A61P3/04 ; A61P3/10
摘要：
The invention encompasses the novel class of compounds represented by formula (I), which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
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