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1.发明公开PHOSPHONIC ACID BIARYL DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) 审中-公开PHOSPHONSÄUREDIARYLERIVATEAS蛋白酪氨酸磷酸酶抑制剂（PTP-1B）
公开(公告)号：EP1244677A1
公开(公告)日：2002-10-02
申请号：EP00986932.2
申请日：2000-12-21
发明人： LAU, Cheuk, Kun , BAYLY, Christopher , GAUTHIER, Jacques, Yves , LEBLANC, Yves , LI, Chun, Sing , ROY, Patrick , THERIEN, Michel , WANG, Zhaoyin
IPC分类号： C07F9/38 , A61K31/66 , C07F9/553 , C07F9/6539 , C07F9/6518 , C07F9/6524 , C07F9/653 , C07F9/6541 , C07F9/6506
CPC分类号： C07F9/65583 , C07F9/65188
摘要： The invention encompasses the novel class of compounds represented by formula (I), which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related conditions.
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2.发明公开ARYL SUBSTITUTED 5,5 FUSED AROMATIC NITROGEN COMPOUNDS AS ANTI-INFLAMMATORY AGENTS 失效芳基取代的5,5-连接的芳族硝基化合物用作抗炎活性成分
公开(公告)号：EP0802917A1
公开(公告)日：1997-10-29
申请号：EP96900215.0
申请日：1996-01-10
发明人： GAUTHIER, Jacques, Yves , LAU, Cheuk, K. , LEBLANC, Yves , LI, Chun-Sing , ROY, Patrick , THERIEN, Michel , WANG, Zhaoyin
CPC分类号： C07D487/04 , C07D513/04
摘要： The invention encompasses the novel compound of formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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3.发明公开5-METHANESULFONAMIDO-1-INDANONES AS AN INHIBITOR OF CYCLOOXYGENASE-2 失效S-METHANSULFONAMIDO-1-INDANONE ALS HEMMER VON CYCLOXYGENASE-2。
公开(公告)号：EP0673366A1
公开(公告)日：1995-09-27
申请号：EP94901716.0
申请日：1993-12-13
发明人： FORD-HUTCHINSON, Anthony, W. , KENNEDY, Brian, P. , PRASIT, Petpiboon , VICKERS, Philip, J. , LU, Chun-Sing , BLACK, Cameron , GUAY, Daniel , LAU, Cheuk, Kun , ROY, Patrick
CPC分类号： C07C311/08 , C07C323/49 , C07C2602/08
摘要： The compound of formula (I') and pharmaceutically acceptable salts therof have been found to be useful in the treatment of inflammation particularly cyclooxygenase mediated diseases including pain, fever and inflammation of a variety of conditions including rheumatic fever, symptoms associated with influenza or other viral infections, common cold, low back and neck pain, dysmenorrhea, headache, toothache, sprains and strains, myositis, neuralgia, synovitis, arthritis, including rheumatoid arthritis degenerative joint diseases (osteoarthritis), gout and ankylosing spondylitis, bursitis, burns, injuries.
摘要翻译： 公开了式I化合物及其药学上可接受的盐在环氧合酶-2介导的疾病的治疗中的用途。
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4.发明公开PHOSPHONIC AND CARBOXYLIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B (PTP-1B) 审中-公开膦的衍生物和羧基的酸作为抑制剂的蛋白酪氨酸磷酸酶-1B（PTP-1B）
公开(公告)号：EP1181309A1
公开(公告)日：2002-02-27
申请号：EP00929175.8
申请日：2000-05-12
发明人： LEBLANC, Yves , DUFRESNE, Claude , ROY, Patrick , WANG, Zhaoyin
CPC分类号： C07K5/0205 , A61K38/00 , C07K5/0202 , C07K5/06191 , C07K5/0827
摘要： The invention encompasses compounds represented by formula (I) as well as compositions and methods of treatment. The compounds are inhibitors of the PTP-1B enzyme.
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5.发明授权5-METHANESULFONAMIDO-1-INDANONES AS AN INHIBITOR OF CYCLOOXYGENASE-2 失效S-甲磺酰氧基-1-INDANONE ALS HEMMER VON CYCLOXYGENASE-2
公开(公告)号：EP0673366B1
公开(公告)日：1998-10-14
申请号：EP94901716.4
申请日：1993-12-13
发明人： FORD-HUTCHINSON, Anthony, W. , KENNEDY, Brian, P. , PRASIT, Petpiboon , VICKERS, Philip, J. , LU, Chun-Sing , BLACK, Cameron , GUAY, Daniel , LAU, Cheuk, Kun , ROY, Patrick
IPC分类号： C07C323/49 , C07C311/24 , C07C323/20 , A61K31/18
CPC分类号： C07C311/08 , C07C323/49 , C07C2602/08
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6.发明公开
公开(公告)号：EP0863891A1
公开(公告)日：1998-09-16
申请号：EP96932417.0
申请日：1996-10-09
发明人： BELLEY, Michel , GAUTHIER, Jacques, Y. , GRIMM, Erich , LEBLANC, Yves , LI, Chung-Sing , THERIEN, Michel , BLACK, Cameron , LAU, Cheuk-Kun , PRASIT, Petpiboon , ROY, Patrick
IPC分类号： C07D333 , A61K31 , A61P25 , A61P29 , A61P43 , C07C317 , C07D213 , C07D307 , C07D405 , C07D407 , C07D409 , C07D417 , C07D471 , C07D491 , C07D495 , C07D498 , C07D513
CPC分类号： C07D405/12 , C07C317/24 , C07C2601/08 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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7.发明公开PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) 审中-公开膦酸衍生物作为蛋白的抑制剂酪氨酸磷酸酶1B（PTP-1B）
公开(公告)号：EP1244678A1
公开(公告)日：2002-10-02
申请号：EP00986935.5
申请日：2000-12-21
发明人： LEBLANC, Yves , DUFRESNE, Claude , GAUTHIER, Jacques, Yves , LAU, Cheuk, Kun , LI, Chun, Sing , ROY, Patrick , THERIEN, Michel , SCHEIGETZ, John , WANG, Zhaoyin
IPC分类号： C07F9/38
CPC分类号： C07F9/6539 , C07F9/3882 , C07F9/4075 , C07F9/4087 , C07F9/65188 , C07F9/65318
摘要： The invention encompasses the novel class of compounds represented by formula (I), which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and conditions related to diabetes.
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8.发明公开PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) 审中-公开膦酸衍生物作为蛋白酪氨酸磷酸酶1B（PTP-1B）抑制剂
公开(公告)号：EP1242432A1
公开(公告)日：2002-09-25
申请号：EP00986934.8
申请日：2000-12-21
发明人： LEBLANC, Yves , LAU, Cheuk, Kun , DUFRESNE, Claude , LI, Chun, Sing , ROY, Patrick , WANG, Zhaoyin , SCHEIGETZ, John , BOYD, Michael
CPC分类号： C07F9/65318 , C07F9/3856 , C07F9/3869 , C07F9/3873 , C07F9/3882 , C07F9/4037 , C07F9/4056 , C07F9/4075 , C07F9/582 , C07F9/65188
摘要： The invention encompasses the novel class of compounds represented by formula (I), which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
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