发明公开
EP1250594A1 SWINE DEFECTIVE FOR TRANSMISSION OF PORCINE ENDOGENOUS RETROVIRUS AND USES THEREOF
审中-公开
猪换的内源性逆转录病毒猪传输不能够，它的使用
- 专利标题： SWINE DEFECTIVE FOR TRANSMISSION OF PORCINE ENDOGENOUS RETROVIRUS AND USES THEREOF
- 专利标题（中）： 猪换的内源性逆转录病毒猪传输不能够，它的使用
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申请号： EP01903145.9申请日： 2001-01-19
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公开(公告)号： EP1250594A1公开(公告)日： 2002-10-23
- 发明人: PATIENCE, Clive
- 申请人： BIOTRANSPLANT, INC
- 申请人地址： Bldg. 75,Third Avenue,Charlestown Navy Yard Charlestown, MA 02129 US
- 专利权人： BIOTRANSPLANT, INC
- 当前专利权人： BIOTRANSPLANT, INC
- 当前专利权人地址： Bldg. 75,Third Avenue,Charlestown Navy Yard Charlestown, MA 02129 US
- 代理机构： LOUIS, PÖHLAU, LOHRENTZ & SEGETH
- 优先权： US177003P 20000119; US182965P 20000216; US243695P 20001027
- 国际公布： WO01053825 20010726
- 主分类号： G01N33/00
- IPC分类号： G01N33/00 ; C12N15/85 ; A61K35/00 ; C12P19/34 ; C12Q1/70
摘要：
Miniature swine whose genomes contain sequences characteristic of pig endogenous retrovirus genes but which are non-infectious to humans are disclosed as sources of organs, tissues and cells for introduction into human recipients afflicted with diseases, or at risk of diseases, whose etiology involves the presence of inadequately functioning organs and for which xenotransplantation of such organs, tissues and cells would have a palliative effect. Methods of producing such animals and for screening animals for the desired properties are also disclosed.
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