发明授权
- 专利标题： Hybrid protease with reduced antigenicity and its use
- 专利标题（中）： 具有抗原性的降低，并且它们的使用混合蛋白酶
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申请号： EP01908667.7申请日： 2001-01-22
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公开(公告)号： EP1254240B1公开(公告)日： 2007-02-28
- 发明人: ESTELL, David, A. , HARDING, Fiona, A.
- 申请人： GENENCOR INTERNATIONAL, INC.
- 申请人地址： 925 Page Mill Road Palo Alto, California 94304 US
- 专利权人： GENENCOR INTERNATIONAL, INC.
- 当前专利权人： GENENCOR INTERNATIONAL, INC.
- 当前专利权人地址： 925 Page Mill Road Palo Alto, California 94304 US
- 代理机构： Kiddle, Simon John
- 优先权： US500135 20000208
- 国际公布： WO2001059130 20010816
- 主分类号： C12N15/55
- IPC分类号： C12N15/55 ; C12N15/56 ; C12N15/57 ; C12N9/56 ; C12N9/54 ; C12N9/64 ; C12N9/20 ; C12N9/42 ; C12N9/24 ; C12N1/21 ; C11D3/386 ; A23K1/165 ; A61K38/46 ; A61K38/47 ; A61K38/48 ; C12Q1/34 ; C12Q1/37 ; G01N33/68
摘要：
The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions. Moreover, naturally occurring proteins are provided.
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