发明公开
- 专利标题： VERFAHREN ZUR HERSTELLUNG VON 1-AMINO-3-ARYL-URACILEN
- 专利标题（英）： Method for the production of 1-amino-3-aryl-uracils
- 专利标题（中）： 用于生产1-氨基-3-芳基 - 尿嘧啶
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申请号： EP01902351.4申请日： 2001-01-25
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公开(公告)号： EP1257540A1公开(公告)日： 2002-11-20
- 发明人: ANDREE, Roland , HOISCHEN, Dorothee , HUPPERTS, Achim , LINKER, Karl-Heinz , WEINTRITT, Holger , WROBLOWSKY, Heinz-Jürgen
- 申请人： Bayer Aktiengesellschaft
- 申请人地址： 51368 Leverkusen DE
- 专利权人： Bayer Aktiengesellschaft
- 当前专利权人： Bayer Aktiengesellschaft
- 当前专利权人地址： 51368 Leverkusen DE
- 优先权： DE10005284 20000207
- 国际公布： WO01058883 20010816
- 主分类号： C07D239/54
- IPC分类号： C07D239/54
摘要：
The invention concerns a novel method for the production of 1-amino-3-aryl-uracil of formula (I), wherein R1 represents optionally substituted alkyl; R2 represents hydrogen, nitro, cyano, halogen or optionally substituted alkyl; R3 represents hydrogen, nitro, cyano or halogen; R4 represents hydrogen, nitro, cyano, carbamoyl, thiocarbamoyl, hydroxy, halogen or optionally substituted alkyl, alkoxy or benzoyloxy and R5 represents hydrogen, hydroxy, mercapto, amino, hydroxyamino, nitro, cyano, carboxy, carbamoyl, Thiocarbamoyl, halogen or one of the following groupings: -R?6, -Q-R6, -NH-R6¿, -NH-O-R6, -NH-SO¿2?-R6, -N(SO2R?6)¿2, -CQ?1-R7, -CQ1-Q2-R6, -CQ1-NH-R6, -Q2-CQ1-R6, -Q2-CQ1-Q2-R6¿, -NH-CQ?1-R6, -N(SO2-R6)-(CQ1-R6¿), -NH-CQ?1-Q2-R6, -Q2-CQ1-NH-R6¿, wherein Q represents O, S, SO or SO¿2?, Q?1 and Q2¿ independently represent O or S and R represents optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl.
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