VERFAHREN ZUR HERSTELLUNG VON 1-AMINO-3-ARYL-URACILEN
    5.
    发明公开
    VERFAHREN ZUR HERSTELLUNG VON 1-AMINO-3-ARYL-URACILEN 审中-公开
    用于生产1-氨基-3-芳基 - 尿嘧啶

    公开(公告)号:EP1257540A1

    公开(公告)日:2002-11-20

    申请号:EP01902351.4

    申请日:2001-01-25

    IPC分类号: C07D239/54

    CPC分类号: C07D239/54

    摘要: The invention concerns a novel method for the production of 1-amino-3-aryl-uracil of formula (I), wherein R1 represents optionally substituted alkyl; R2 represents hydrogen, nitro, cyano, halogen or optionally substituted alkyl; R3 represents hydrogen, nitro, cyano or halogen; R4 represents hydrogen, nitro, cyano, carbamoyl, thiocarbamoyl, hydroxy, halogen or optionally substituted alkyl, alkoxy or benzoyloxy and R5 represents hydrogen, hydroxy, mercapto, amino, hydroxyamino, nitro, cyano, carboxy, carbamoyl, Thiocarbamoyl, halogen or one of the following groupings: -R?6, -Q-R6, -NH-R6¿, -NH-O-R6, -NH-SO¿2?-R6, -N(SO2R?6)¿2, -CQ?1-R7, -CQ1-Q2-R6, -CQ1-NH-R6, -Q2-CQ1-R6, -Q2-CQ1-Q2-R6¿, -NH-CQ?1-R6, -N(SO2-R6)-(CQ1-R6¿), -NH-CQ?1-Q2-R6, -Q2-CQ1-NH-R6¿, wherein Q represents O, S, SO or SO¿2?, Q?1 and Q2¿ independently represent O or S and R represents optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl.