A novel mechanical stimulus-responsive channel protein originating in mouse or humans which is expressed specifically in the kidney and has a function of non-selectively incorporating cation into cells respondent to a mechanical stimulus; a DNA encoding this protein; a method of screening a cation channel activity enhancer or inhibitor with the use of this protein; and an antibody against this protein. The above-described protein is useful as a diagnostic or a remedy for diseases based on abnormalities in the cation channel such as hypertension or diabetes or as a tool for searching for preventives and/or remedies for these diseases.