发明公开
- 专利标题： MAUROCALCINE, ANALOGUES THEREOF AND THEIR THERAPEUTICAL USES
- 专利标题（中）： MAUROCALCINE，其类似物及其治疗应用
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申请号： EP01936061.9申请日： 2001-03-05
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公开(公告)号： EP1263783A2公开(公告)日： 2002-12-11
- 发明人: KHARRAT, Riad, , MABROUK, Kamel , EL-AYEB, Mohammed , ROCHAT, Hervé , SABATIER, Jean-Marc
- 申请人： Cellpep S.A.
- 申请人地址： 16, rue de la Banque 75002 Paris FR
- 专利权人： Cellpep S.A.
- 当前专利权人： Cellpep S.A.
- 当前专利权人地址： 16, rue de la Banque 75002 Paris FR
- 代理机构： McKelvey, Ian Edward
- 优先权： GB0005124 20000303
- 国际公布： WO01064724 20010907
- 主分类号： C07K14/435
- IPC分类号： C07K14/435
摘要：
Maurocalcine, a novel toxin isolated from the venom of the Tunisian chactidae scorpion Scorpio maurus palmatus, has the amino acid sequence GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR (SEQ. ID. No. 1). It potently and reversibly modifies channel gating behaviour of type 1 ryanodine receptor (RyR1) by inducing prominent subconductance behavior. Maurocalcine and its bioactive structural analogues - preferably those containing the KKCKRR motif corresponding to part of the II-III loop of the alpha1S subunit of the voltage-dependent skeletal muscle calcium channel dihydropyridine receptor - appear to possess a therapeutic potential, notably as candidate immuno-suppressive drugs, and for the treatment of pathologies in humans that may involve a dysfunction of calcium channels.
公开/授权文献
- EP1263783B1 MAUROCALCINE, ANALOGUES THEREOF AND THEIR THERAPEUTICAL USES 公开/授权日：2007-01-17
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