发明授权
- 专利标题： METHODS FOR GENERATING HYPERMUTABLE BACTERIA
- 专利标题（中）： 法生产细菌hypermutating
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申请号： EP01907187.7申请日： 2001-02-12
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公开(公告)号： EP1268765B1公开(公告)日： 2008-08-13
- 发明人: NICOLAIDES, Nicholas, C. , SASS, Philip, M. , GRASSO, Luigi , VOGELSTEIN, Bert , KINZLER, Kenneth, W.
- 申请人： THE JOHNS HOPKINS UNIVERSITY , Morphotek, Inc.
- 申请人地址： Suite 906, 111 Market Place Baltimore, MD 21202 US
- 专利权人： THE JOHNS HOPKINS UNIVERSITY,Morphotek, Inc.
- 当前专利权人： THE JOHNS HOPKINS UNIVERSITY,Morphotek, Inc.
- 当前专利权人地址： Suite 906, 111 Market Place Baltimore, MD 21202 US
- 代理机构： Tombling, Adrian George
- 优先权： US181929P 20000211
- 国际公布： WO2001059092 20010816
- 主分类号： C12N15/10
- IPC分类号： C12N15/10 ; C12N1/20
摘要：
Bacteria are manipulated to create desirable output traits using dominant negative alleles of mismatch repair proteins. Enhanced hypermutation is achieved by combination of mismatch repair deficinecy and exogenously applied mutagens. Stable bacteria containing desirable output traits are obtained by restoring mismatch reparir activity to the bacteria.
公开/授权文献
- EP1268765A2 METHODS FOR GENERATING HYPERMUTABLE BACTERIA 公开/授权日：2003-01-02
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