发明授权
- 专利标题: Particulate construct comprising polyhydroxyalkanoate and method for producing it
- 专利标题(中): 基于聚羟基烷酸酯颗粒和它们的制备方法
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申请号: EP02015357.3申请日: 2002-07-10
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公开(公告)号: EP1275378B1公开(公告)日: 2009-04-15
- 发明人: Yano, Tetsuya , Nomoto, Tsuyoshi , Kozaki, Shinya , Honma, Tsutomu
- 申请人: CANON KABUSHIKI KAISHA
- 申请人地址: 30-2, Shimomaruko 3-chome Ohta-ku Tokyo 146-8501 JP
- 专利权人: CANON KABUSHIKI KAISHA
- 当前专利权人: CANON KABUSHIKI KAISHA
- 当前专利权人地址: 30-2, Shimomaruko 3-chome Ohta-ku Tokyo 146-8501 JP
- 代理机构: Weser, Wolfgang
- 优先权: JP2001210040 20010710; JP2001210041 20010710; JP2001210043 20010710; JP2001210055 20010710
- 主分类号: A61K9/16
- IPC分类号: A61K9/16 ; A61K9/50 ; C12P7/62 ; A61K49/22 ; B01J13/02 ; A61K8/00
摘要:
The invention provides a particulate construct such as microcapsules containing a drug, and serving a slow releasing preparation not associated with a practically unacceptable initial burst release but showing a practically acceptable zero-order release for a certain period and a producing method for such particulate construct, and a slow releasing preparation of a high drug content capable of stably incorporating the drug in the particulate construct such as microcapsules, and a producing method for such preparation. The invention also provides a particulate construct such as microcapsules utilizing a highly functional polymer compound and incorporating oil phase and/or water phase in solid phase, and a producing method therefor. Furthermore, the invention provides a particulate construct such as microcapsules having a hollow structure of a single polymer membrane as the outer shell and capable of containing many bubbles in the fine particles, and a producing method capable of preparing such construct with a high reproducibility. According to the invention, a particulate construct such as microcapsules is formed with polyhydroxyalkanoate of a specified structure and a drug for a desired purpose, an oil phase and/or a water phase, or a gaseous phase is included in such construct.
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