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1.发明公开Evaluation probe for central nervous system permeability, evaluation method for central nervous system permeability, and screening method using an evaluation probe for central nervous system permeability 审中-公开探测中枢神经系统的渗透性的分析，对中枢神经系统和扫描与探针的磁导率的分析方法，用于分析所述中枢神经系统的渗透性
公开(公告)号：EP2489665A1
公开(公告)日：2012-08-22
申请号：EP12001025.1
申请日：2012-02-16
发明人： Tanaka, Toshio , Watanabe, Kohei , Nomoto, Tsuyoshi , Okano, Mie , Shintou, Taichi , Miyazaki, Takeshi , Nishimura, Yuhei , Shimada, Yasuhito
IPC分类号： C07D417/06 , C07D417/14 , C09B23/04 , C09B23/10 , G01N33/50 , G01N33/58
CPC分类号： C07D417/06 , C07D417/14 , C09B23/04 , C09B23/06 , G01N33/5082 , G01N33/5088 , G01N2333/4603 , G01N2800/28
摘要： Provided is an evaluation probe capable of optically evaluating permeability of a substance through a central nervous system tissue. Also provided is an evaluation method for permeability of a substance through a central nervous system tissue using an evaluation probe for central nervous system permeability. Also provided is a screening method using an evaluation probe for central nervous system permeability. The evaluation probe for central nervous system permeability includes, as an active ingredient, at least one kind of compound represented by the following general formula (1).
General formula (1)摘要翻译： 本发明提供一种能够通过中枢神经系统组织的光学评估的物质的渗透性的评价试验。 如此提供的样品是通过使用在评估中枢神经系统渗透性的中枢神经系统组织用于物质的渗透性的评价方法。 这样提供了一种使用在评估中枢神经系统渗透性试验的筛选方法。 对于中枢神经系统的渗透性的评价试验中，作为活性成分的，至少一种化合物由下述通式（1）表示。 通式（1）
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2.发明授权Particulate construct comprising polyhydroxyalkanoate and method for producing it 有权基于聚羟基烷酸酯颗粒和它们的制备方法
公开(公告)号：EP1275378B1
公开(公告)日：2009-04-15
申请号：EP02015357.3
申请日：2002-07-10
CPC分类号： A61K8/11 , A61K8/35 , A61K9/5031 , A61K47/6925 , A61K49/223 , A61K2800/412 , A61Q17/04 , B01J13/04 , B01J13/06 , B01J13/14 , Y02A50/473
摘要： The invention provides a particulate construct such as microcapsules containing a drug, and serving a slow releasing preparation not associated with a practically unacceptable initial burst release but showing a practically acceptable zero-order release for a certain period and a producing method for such particulate construct, and a slow releasing preparation of a high drug content capable of stably incorporating the drug in the particulate construct such as microcapsules, and a producing method for such preparation. The invention also provides a particulate construct such as microcapsules utilizing a highly functional polymer compound and incorporating oil phase and/or water phase in solid phase, and a producing method therefor. Furthermore, the invention provides a particulate construct such as microcapsules having a hollow structure of a single polymer membrane as the outer shell and capable of containing many bubbles in the fine particles, and a producing method capable of preparing such construct with a high reproducibility. According to the invention, a particulate construct such as microcapsules is formed with polyhydroxyalkanoate of a specified structure and a drug for a desired purpose, an oil phase and/or a water phase, or a gaseous phase is included in such construct.
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3.发明公开Immunoassay, reagent for immunoassay, and production method of the same 有权Immuntestverfahren，ReagenzfürImmuntestverfahren und Verfahren zu dessen Herstellung
公开(公告)号：EP1371983A1
公开(公告)日：2003-12-17
申请号：EP03012945.6
申请日：2003-06-06
IPC分类号： G01N33/543 , C07K4/00
CPC分类号： G01N33/54353 , C07K7/06 , G01N33/585
摘要： An assay method for determining presence of a target antibody or antigen in a specimen qualitatively or quantitatively by mixing the specimen with an antigen or antibody immunologically reactive with the target antibody or antigen, and assaying the level of the immunological agglutination reaction, wherein the reactive antigen or antibody is effectively immobilized on the carrier via an amino acid sequence capable of binding to the carrier.
摘要翻译： 一种用于通过将样品与抗原或抗体与靶抗体或抗原免疫反应的抗原或抗体定性或定量地测定样品中目标抗体或抗原的存在以及测定免疫凝集反应的水平的测定方法，其中所述反应性抗原 或抗体通过能够结合载体的氨基酸序列有效地固定在载体上。
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公开(公告)号：EP1253476A3
公开(公告)日：2003-10-22
申请号：EP02009694.7
申请日：2002-04-29
IPC分类号： G03G9/087 , C09C3/10 , C09D167/04
CPC分类号： G03G9/09 , G03G9/08755 , Y10T428/2993 , Y10T428/2998
摘要： A capsular structure is provided which does not cause load to the environment and the living things, produced by utilizing PHA having various functionality, enclosing cores at a high density without limitation of the core material. The granular structure has granules coated at least partly with a polyhydroxyalkanoate constituted of monomer units of at least one of 3-hydroxypropionic acid, 3-hydorxy-n-butyric acid, and 3-hydroxy-n-valeric acid.
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5.发明公开Electrostatic charge image developing toner, producing method therefor, and image forming method and image forming apparatus utilizing the toner 有权Elektrostatischer Ladungsaufzeichnungstoner，Herstellungsverfahren，Bilderzeugungsverfahren und Bildherstellungsapparat
公开(公告)号：EP1253475A2
公开(公告)日：2002-10-30
申请号：EP02009673.1
申请日：2002-04-29
IPC分类号： G03G9/087
CPC分类号： G03G9/09733 , C01P2002/86 , C01P2002/88 , C01P2004/03 , C01P2004/50 , C01P2004/51 , C01P2004/61 , C01P2004/62 , C01P2004/84 , C01P2006/60 , C01P2006/90 , C08G63/06 , C08G63/6882 , C12P7/625 , C12P11/00 , G03G9/08755 , G03G9/08791 , G03G9/08795 , G03G9/08797 , G03G9/09758 , G03G9/09775
摘要： Electrostatic charge image developing toner allows to design the toner characteristics such as chargeability, flowability, stability in time and environmental stability uniform among the toners of different colors. The toner has a small particle size enough for enabling uniform dispersion and being excellent in color saturation and transparency. The toner also shows higher contribution to the environmental security. The toner includes a coloring agent of which at least a part of the surface is covered with polyhydroxyalkanoate (PHA). The toner is produced by dispersing the coloring agent in aqueous medium, then fixing PHA synthesizing enzyme to the coloring agent dispersed in the aqueous medium, then adding 3-hydroxyacyl CoA, and executing a PHA synthesizing reaction to cover at least a part of the surface of the coloring agent with PHA. The toner thus obtained is used for an image forming method.
摘要翻译： 静电荷图像显影调色剂允许设计不同颜色的调色剂之间的调色剂特性如充电性，流动性，时间稳定性和环境稳定性。 调色剂具有足够小的粒径以使得能够均匀分散并且具有优异的色饱和度和透明度。 调色剂对环境安全的贡献也更大。 调色剂包括其表面的至少一部分被聚羟基链烷酸酯（PHA）覆盖的着色剂。 调色剂通过将着色剂分散在水性介质中，然后将PHA合成酶固定在分散在水性介质中的着色剂上，然后加入3-羟酰基CoA，并执行PHA合成反应以覆盖表面的至少一部分 的着色剂与PHA。 由此获得的调色剂用于图像形成方法。
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公开(公告)号：EP0767384A3
公开(公告)日：1998-03-11
申请号：EP96120379.1
申请日：1992-09-08
CPC分类号： G01N33/6833 , G01N33/92 , Y10T436/10 , Y10T436/104165 , Y10T436/105831
摘要： Lipid is determined quantitatively by treating a sample with a surfactant in an aqueous medium to obtain a liquid sample dispersion, then reacting the dispersion with a reagent containing cupric ion and bicinchoninic acid, and measuring a colored state developed by complex formation of bicinchoninic acid with cuprous ion formed from cupric ion in the presence of lipid. This method can be effectively applied to determination of amphiphilic lipid having a tendency of gathering in an aqueous medium. Further, two different species interfering with each other in quantitative determination thereof are determined respectively by conducting two different determination methods on the same sample followed by calculation using the values obtained.
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7.发明公开Probe for a hair cell, and labelling method for a hair cell using the probe for a hair cell 有权Haarzellen和Haarzellen的Haarzellens mit der SondefürHaarzellen
公开(公告)号：EP2204194A2
公开(公告)日：2010-07-07
申请号：EP09015904.7
申请日：2009-12-22
发明人： Nomoto, Tsuyoshi , Miyazaki, Takeshi , Watanabe, Kohei , Shintou, Taichi , Takahashi, Kaoru , Tanaka, Toshio , Nishimura, Yuhei , Shimada, Yasuhito , Nishimura, Norihiro
IPC分类号： A61K49/00 , G01N33/533
CPC分类号： G01N33/5005 , A61K49/0032 , A61K49/0041 , A61K49/006 , C09B11/24 , C09B23/0016 , C09B23/0058 , C09B23/0066 , C09B23/0075 , C09B23/06 , C09B23/105 , C09B23/107 , G01N33/5044 , G01N33/6893 , G01N2800/14 , G01N2800/20
摘要： Provided are a novel probe for a hair cell for clearly identifying various conditions of a hair cell, and a labelling method for a hair cell using the probe for a hair cell, more particularly, a probe for a hair cell containing, as an active agent, at least one kind selected from staining compounds represented by one of the general formulae (I) and (II), and a labelling method for a hair cell using the probe for a hair cell.
摘要翻译： 提供一种用于毛细胞的新型探针，用于清楚地识别毛细胞的各种条件，以及使用毛细胞探针的毛细胞的标记方法，更具体地，涉及含有作为活性剂的毛细胞的探针 ，选自由通式（I）和（II）之一表示的染色化合物中的至少一种，以及使用毛细胞探针的毛细胞的标记方法。
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8.发明公开Enzyme electrode, enzyme electrode producing method, sensor and fuel cell each using enzyme electrode 审中-公开Enzymelektrode，Herstellungsverfahrendafürsowie diese verwendender传感器和Brennstoffzelle
公开(公告)号：EP1892529A1
公开(公告)日：2008-02-27
申请号：EP07016479.3
申请日：2007-08-22
发明人： Kubo, Wataru , Nomoto, Tsuyoshi
IPC分类号： G01N33/53
CPC分类号： C12Q1/001 , H01M4/90 , H01M8/16 , Y02E60/527 , Y02P70/56
摘要： An amino acid (1040) capable of coordinately binding to a metallic complex (1020) is introduced to an active site (1030) within the enzyme (1000) or another controlled position near the active site. Therefore, when a mediator is introduced into the enzyme, a mediator-introduced position is controlled to be held at or near the active site.
摘要翻译： 能够与金属络合物（1020）配位结合的氨基酸（1040）被引入酶（1000）内的活性位点（1030）或活性位点附近的另一受控位置。 因此，当将介体引入酶时，介导介质位置被控制在活性位点处或附近。
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公开(公告)号：EP1256606B1
公开(公告)日：2006-03-08
申请号：EP02009670.7
申请日：2002-04-29
CPC分类号： C09D11/322 , C08G63/6882 , C12P7/625 , C12P11/00 , Y10T428/254 , Y10T428/2991
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10.发明公开Particulate construct comprising polyhydroxyalkanoate and method for producing it 有权基于聚羟基烷酸酯颗粒和它们的制备方法
公开(公告)号：EP1275378A3
公开(公告)日：2003-10-15
申请号：EP02015357.3
申请日：2002-07-10
CPC分类号： A61K8/11 , A61K8/35 , A61K9/5031 , A61K47/6925 , A61K49/223 , A61K2800/412 , A61Q17/04 , B01J13/04 , B01J13/06 , B01J13/14 , Y02A50/473
摘要： The invention provides a particulate construct such as microcapsules containing a drug, and serving a slow releasing preparation not associated with a practically unacceptable initial burst release but showing a practically acceptable zero-order release for a certain period and a producing method for such particulate construct, and a slow releasing preparation of a high drug content capable of stably incorporating the drug in the particulate construct such as microcapsules, and a producing method for such preparation. The invention also provides a particulate construct such as microcapsules utilizing a highly functional polymer compound and incorporating oil phase and/or water phase in solid phase, and a producing method therefor. Furthermore, the invention provides a particulate construct such as microcapsules having a hollow structure of a single polymer membrane as the outer shell and capable of containing many bubbles in the fine particles, and a producing method capable of preparing such construct with a high reproducibility. According to the invention, a particulate construct such as microcapsules is formed with polyhydroxyalkanoate of a specified structure and a drug for a desired purpose, an oil phase and/or a water phase, or a gaseous phase is included in such construct.
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