发明授权
- 专利标题： CHROMAN DERIVATIVES AS ESTROGENIC COMPOUNDS
- 专利标题（中）： 色当雌激素CONNECTIONS
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申请号： EP01929361.2申请日： 2001-02-26
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公开(公告)号： EP1282615B1公开(公告)日： 2011-10-19
- 发明人: VEENEMAN, Gerrit, Herman , TEERHUIS, Neeltje, Miranda
- 申请人： N.V. Organon
- 申请人地址： Kloosterstraat 6 5349 AB Oss NL
- 专利权人： N.V. Organon
- 当前专利权人： N.V. Organon
- 当前专利权人地址： Kloosterstraat 6 5349 AB Oss NL
- 代理机构： Kraak, Hajo
- 优先权： EP00200713 20000301
- 国际公布： WO2001064665 20010907
- 主分类号： C07D311/60
- IPC分类号： C07D311/60 ; A61K31/35 ; A61P5/30
摘要：
The invention provides chroman compounds having Formula (1), wherein R1 is (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl, and independently R1 has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skeleton; R4 is Hal, CF¿3?, OH or (1C-2C)alkyloxy; R?2, R3, and R5¿ are independently H, Hal, CF¿3?, (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl and prodrugs thereof for the manufacture of a medicine for estrogen-receptor related treatments.
公开/授权文献
- EP1282615A1 CHROMAN DERIVATIVES AS ESTROGENIC COMPOUNDS 公开/授权日：2003-02-12
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