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220 条记录 (耗时 0.029 秒)

    INTRAUTERINE SYSTEM FOR USE IN MEDICAL TREATMENT
    1.
    发明公开
    INTRAUTERINE SYSTEM FOR USE IN MEDICAL TREATMENT 审中-公开
    宫内FOR USE IN药物治疗

    公开(公告)号：EP2427154A1

    公开(公告)日：2012-03-14

    申请号：EP10715875.0

    申请日：2010-05-03

    申请人： N.V. Organon

    发明人： DE GRAAFF, Wouter ,  VEENSTRA, Harm ,  MULDERS, Titia Martine Truce

    IPC分类号： A61F6/14 ,  A61K9/00

    CPC分类号： A61M31/002 ,  A61F6/144 ,  A61F13/26 ,  A61K9/0039 ,  Y10T29/49826

    摘要： An intrauterine system (1) is disclosed for use in the treatment of dysfunctional uterine bleeding; menorraghia; dysmenorrhoea; endometriosis; uterine fibroids; climacteric complaints; osteoporosis; and urogenital atrophy. The system is formed by a frame (16) defining an interior space (20) for receipt of a deposit (22) of a therapeutically effective dose of a biologically active compound. The frame has an open structure allowing access to a substantial part of an outer surface of the deposit, and the deposit has a rate controlling structure (26) that controls a rate of release of the compound within the uterus. One or more retention elements (6) are provided on the frame for retaining the frame within the uterus of a female mammal.

    CHROMAN DERIVATIVES AS ESTROGENIC COMPOUNDS
    3.
    发明授权
    CHROMAN DERIVATIVES AS ESTROGENIC COMPOUNDS 有权
    色当雌激素CONNECTIONS

    公开(公告)号：EP1282615B1

    公开(公告)日：2011-10-19

    申请号：EP01929361.2

    申请日：2001-02-26

    申请人： N.V. Organon

    发明人： VEENEMAN, Gerrit, Herman ,  TEERHUIS, Neeltje, Miranda

    IPC分类号： C07D311/60 ,  A61K31/35 ,  A61P5/30

    CPC分类号： C07D311/60

    摘要： The invention provides chroman compounds having Formula (1), wherein R1 is (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl, and independently R1 has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skeleton; R4 is Hal, CF¿3?, OH or (1C-2C)alkyloxy; R?2, R3, and R5¿ are independently H, Hal, CF¿3?, (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl and prodrugs thereof for the manufacture of a medicine for estrogen-receptor related treatments.

    ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN
    5.
    发明公开
    ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN 有权
    （吡咯烷-2-基）FOR USE IN治疗疼痛的苯基衍生物

    公开(公告)号：EP2356105A1

    公开(公告)日：2011-08-17

    申请号：EP09744410.3

    申请日：2009-11-03

    申请人： N.V. Organon

    发明人： GROVE, Simon, James, Anthony ,  MISTRY, Ashvinkumar, Dhirubhai ,  PALIN, Ronald ,  MACLEAN, John, Kinnaird, Ferguson

    IPC分类号： C07D401/10 ,  A61K31/4439 ,  A61P25/02

    CPC分类号： C07D401/10

    摘要： The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula (I), wherein R
    1 is (C
    1-4 )alkyl, halo(C
    1-4 )alkyl, (C
    1-4 )alkyloxy, or halo(C
    1-4 )alkyloxy; R
    2 is H, (C
    1-4 )alkyl, halo(C
    1-4 )alkyl, (C
    1-4 )alkyloxy, halo(C
    1-4 )alkyloxy or halogen; R
    3 is H, (C
    1-4 )alkyl or halo(C
    1-4 )alkyl; R
    4 is H, (C
    1-4 )alkyl or halo(C
    1-4 )alkyl; R
    5 is H, (C
    1-4 )alkyl or halo(C
    1-4 )alkyl; or R4 and R5, when bonded to the same carbon atom, can together with the carbon atom form a spiro(C
    3-6 )cycloalkyl group, optionally substituted with halogen; R
    6 is H, (C
    1-4 )alkyl, halo(C
    1-4 )alkyl, (C
    1-4 )alkyloxy, halo(C
    1-4 )alkyloxy or halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these (pyrrolidin-2-yl)phenyl derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.

    DIHYDROPYRIDINE DERIVATIVES
    6.
    发明授权
    DIHYDROPYRIDINE DERIVATIVES 有权
    二氢吡啶衍生物

    公开(公告)号：EP1879866B1

    公开(公告)日：2011-03-16

    申请号：EP05738155.0

    申请日：2005-05-04

    申请人： N.V. Organon

    发明人： VAN STRATEN, Nicole, Corine Renee ,  GERRITSMA, Gerritdina Geziena ,  VAN DER VEEN, Lars Anders

    IPC分类号： C07D215/54 ,  A61K31/47 ,  A61P5/06

    CPC分类号： C07D215/54

    摘要： The present invention relates to dihydropyridine derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, phenyl, (1-5C)heteroaryl R2, R3 are independently (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (2­4C)alkenyloxy, (2-4C)alkynyloxy, halogen X is SO2, CH2, C(O) or X is absent R4 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl, (2-6C)heterocycloalkyl(1­4C)alkyl, (6-1 OC)aryl, (6-10C)aryl(1-4C)alkyl, (1-9C)heteroaryl or (1-9C)heteroaryl(1­4C)alkyl. The compounds are useful for the treatment of fertility disorders.

    A METHOD OF HORMONE SUPPRESSION IN HUMANS
    10.
    发明公开
    A METHOD OF HORMONE SUPPRESSION IN HUMANS 审中-公开
    在人类激素抑制物质

    公开(公告)号：EP2207542A2

    公开(公告)日：2010-07-21

    申请号：EP08847867.2

    申请日：2008-11-04

    申请人： N.V. Organon

    发明人： HANSSEN, Robert, Gerard, Jules, Marie ,  SCHIPPER, Jacques ,  SCHOEMAKER, Josephus, Hubertus

    IPC分类号： A61K31/198 ,  A61P15/00 ,  A61P15/18 ,  A61P15/08

    CPC分类号： A61K31/198

    摘要： The present invention relates to a glycine transporter-1 inhibitor having the formula (I) wherein X is 1-3 substituents selected from H, halogen, methyl, methoxy, trifluoromethyl and trifluoromethoxy and Y is 1-3 substituents selected from H, methyl and halogen or a pharmaceutically acceptable salt thereof for use in a treatment in humans to suppress the level of one or more hormone selected from luteinizing hormone, follicle-stimulating hormone, estradiol and testosterone. The present invention further relates to such a glycine transporter-1 inhibitor as part of a contraceptive regimen or as a treatment for hypersexuality.