发明授权
- 专利标题： DIAGNOSIS OF LIVER FIBROSIS WITH SERUM MARKER ALGORITHMS
- 专利标题（中）： 肝纤维化的诊断中的应用血清标志物算法
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申请号： EP01945050.1申请日： 2001-04-26
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公开(公告)号： EP1283989B1公开(公告)日： 2007-07-11
- 发明人: VÖLKER, Michael , BECKA, Michael , KROLL, Werner , KNORR, Andreas , UNGER, Sylvia , GEHRMANN, Mathias , HENNIG, Guido , BURCHARDT, Elmar-Reinhold , ARTHUR, Michael, J. , BURT, Alastair, D. , PINZANI, Massimo , SCHUPPAN, Detlef
- 申请人： Bayer Aktiengesellschaft , BAYER CORPORATION
- 申请人地址： 51368 Leverkusen DE
- 专利权人： Bayer Aktiengesellschaft,BAYER CORPORATION
- 当前专利权人： Bayer Aktiengesellschaft,BAYER CORPORATION
- 当前专利权人地址： 51368 Leverkusen DE
- 代理机构： Linkenheil, Dieter
- 优先权： EP00109063 20000428; ITMI000813 20010413
- 国际公布： WO2001086304 20011115
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; G01N33/573
摘要：
The present invention concerns a method for diagnosing liver fibrosis wherein two or more diagnostic markers are measured and the measurements are correlated by a mathematic algorithm characterized in that the diagnostic markers are selected from the group N-terminal procollagen III propeptide (PIIINP), Collagen IV, Collagen VI, Tenascin, Laminin, Hyaluronan, MMP-2, TIMP-1 and MMP-9/TIMP-1 complex. The algorithm can be used to predict the histological score of a liver biopsy.
公开/授权文献
- EP1283989A2 DIAGNOSIS OF LIVER FIBROSIS WITH SERUM MARKER ALGORITHMS 公开/授权日：2003-02-19
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