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公开(公告)号:EP1283989B1
公开(公告)日:2007-07-11
申请号:EP01945050.1
申请日:2001-04-26
发明人: VÖLKER, Michael , BECKA, Michael , KROLL, Werner , KNORR, Andreas , UNGER, Sylvia , GEHRMANN, Mathias , HENNIG, Guido , BURCHARDT, Elmar-Reinhold , ARTHUR, Michael, J. , BURT, Alastair, D. , PINZANI, Massimo , SCHUPPAN, Detlef
IPC分类号: G01N33/68 , G01N33/573
CPC分类号: G01N33/6893 , G01N33/6887 , G01N2333/47 , G01N2333/78 , G01N2333/8146 , G01N2333/96486 , G01N2800/085
摘要: The present invention concerns a method for diagnosing liver fibrosis wherein two or more diagnostic markers are measured and the measurements are correlated by a mathematic algorithm characterized in that the diagnostic markers are selected from the group N-terminal procollagen III propeptide (PIIINP), Collagen IV, Collagen VI, Tenascin, Laminin, Hyaluronan, MMP-2, TIMP-1 and MMP-9/TIMP-1 complex. The algorithm can be used to predict the histological score of a liver biopsy.
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公开(公告)号:EP1283989A2
公开(公告)日:2003-02-19
申请号:EP01945050.1
申请日:2001-04-26
发明人: VÖLKER, Michael , BECKA, Michael , KROLL, Werner , KNORR, Andreas , UNGER, Sylvia , GEHRMANN, Mathias , HENNIG, Guido , BURCHARDT, Elmar-Reinhold , ARTHUR, Michael, J. , BURT, Alastair, D. , PINZANI, Massimo , SCHUPPAN, Detlef
IPC分类号: G01N33/68 , G01N33/573
CPC分类号: G01N33/6893 , G01N33/6887 , G01N2333/47 , G01N2333/78 , G01N2333/8146 , G01N2333/96486 , G01N2800/085
摘要: The present invention concerns a method for diagnosing liver fibrosis wherein two or more diagnostic markers are measured and the measurements are correlated by a mathematic algorithm characterized in that the diagnostic markers are selected from the group N-terminal procollagen III propeptide (PIIINP), Collagen IV, Collagen VI, Tenascin, Laminin, Hyaluronan, MMP-2, TIMP-1 and MMP-9/TIMP-1 complex. The algorithm can be used to predict the histological score of a liver biopsy.
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