发明公开
EP1288220A2 Neuroactive 3.alpha.-hydroxy-steroids of the androstane and pregnane series
失效
Neuroaktive 3.alpha.-Androstan und-Pseudan Steroide
- 专利标题： Neuroactive 3.alpha.-hydroxy-steroids of the androstane and pregnane series
- 专利标题（中）： Neuroaktive 3.alpha.-Androstan und-Pseudan Steroide
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申请号： EP02025321.7申请日： 1996-06-06
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公开(公告)号： EP1288220A2公开(公告)日： 2003-03-05
- 发明人: Upasani, Ravindra B. , Hogenkamp, Derk J. , Fick, David B. , Lan, Nancy C.
- 申请人： Purdue Pharma Ltd.
- 申请人地址： 201 Technology Drive Irvine, CA 92618 US
- 专利权人： Purdue Pharma Ltd.
- 当前专利权人： Purdue Pharma Ltd.
- 当前专利权人地址： 201 Technology Drive Irvine, CA 92618 US
- 代理机构： Chapman, Paul William
- 优先权： US467404 19950606
- 主分类号： C07J1/00
- IPC分类号： C07J1/00 ; C07J17/00 ; C07J21/00 ; C07J31/00 ; C07J41/00 ; C07J43/00
摘要：
The invention relates to a 3α-hydroxy, 17-(un)substituted derivatives of the androstane series and 3α-hydroxy, 21-substituted derivatives of the pregnane series. These derivatives are capable of acting at the recently identified site on the GRC, thereby modulating brain excitability in a manner that will alleviate stress, anxiety, insomnia, mood disorders that are amenable to GRC-active agents (such as depression) and seizure activity. The steroid derivatives of this invention are those having general structural formula (I), wherein R, R 1 , R 2 , R 3 ,R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are further defined herein and the dotted lines are single or double bonds. The structure includes androstanes pregnanes (R 4 = methyl), 19-norandrostanes, and norpregnanes (R 4 =H).
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