Compounds of the general formula (1) or pharmacologically acceptable salts thereof, exhibiting thrombopoietin-like activities: wherein E is methylidyne or nitrilo; R1 is optionally substituted aryl or optionally substituted heteroaryl; R2 is hydrogen or alkyl; W1 is an amino acid residue; A is carbonyl or sulfonyl; X1 is optionally substituted alkylene or optionally substituted alkenylene; and p is 0 or 1.