发明授权
- 专利标题: VERBINDUNGEN MIT EINER SULFONAMIDGRUPPE UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
- 专利标题(英): Compounds with a sulphonamide group and pharmaceutical compositions containing these compounds
- 专利标题(中): 具有磺酰THEM化合物和药物组合物含
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申请号: EP01943329.1申请日: 2001-05-08
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公开(公告)号: EP1294402B2公开(公告)日: 2009-08-12
- 发明人: ELGER, Walter , HILLISCH, Alexander , HEDDEN, Annemarie , SCHWARZ, Sigfrid , SCHÖLLKOPF, Klaus
- 申请人: Bayer Schering Pharma Aktiengesellschaft
- 申请人地址: Müllerstrasse 178 13353 Berlin DE
- 专利权人: Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人: Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人地址: Müllerstrasse 178 13353 Berlin DE
- 代理机构: Weiss, Wolfgang
- 优先权: DE10027887 20000531
- 国际公布: WO2001091797 20011206
- 主分类号: A61K47/20
- IPC分类号: A61K47/20 ; A61K31/565 ; A61K31/566 ; A61K31/568 ; A61K31/49 ; A61K31/4045 ; A61P43/00
摘要:
The invention relates to compounds which, acting as a prodrug and/or support, enable an active agent to be taken up by the erythrocytes and/or an active agent to bind to the erythrocytes. The uptake of these compounds by and/or the binding thereof to the erythrocytes is made possible by a group of formula -SO2NR R , wherein R and R , independently of each other, mean a hydrogen atom, an acyl group, an alkyl group, a cycloalkyl group, an aryl group, a cyano group or a hydroxy group. The inventive prodrugs enable active agents such as endogenic substances, natural substances and synthetic substances with therapeutically useful properties which have a high "first path" effect, to be administered orally effectively or significantly improve the oral activity thereof.
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