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发明公开
EP1299110A2 COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES, TAXANES AND/OR ANTIMETABOLITES 有权
联合肿瘤的治疗基于偏端霉素衍生物丙烯及抗代谢基金

  • 专利标题： COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES, TAXANES AND/OR ANTIMETABOLITES
  • 专利标题（中）： 联合肿瘤的治疗基于偏端霉素衍生物丙烯及抗代谢基金
  • 申请号： EP01945297.8
    申请日： 2001-06-20
  • 公开(公告)号： EP1299110A2
    公开(公告)日： 2003-04-09
  • 发明人: GERONI, Maria, Cristina, Rosa , COZZI, Paolo , BERIA, Italo
  • 申请人： Pharmacia Italia S.p.A.
  • 申请人地址： Via Robert Koch 1.2 20152 Milano IT
  • 专利权人： Pharmacia Italia S.p.A.
  • 当前专利权人： Pharmacia Italia S.p.A.
  • 当前专利权人地址： Via Robert Koch 1.2 20152 Milano IT
  • 优先权： GB0015446 20000623
  • 国际公布： WO01097618 20011227
  • 主分类号： A61K31/70
  • IPC分类号： A61K31/70
COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES, TAXANES AND/OR ANTIMETABOLITES
摘要：
The present invention provides the combined use of acryloyl distamycin derivatives, in particular α-bromo- and -α-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, antimicrotubule agents and/or an antimetabolites. Also provided is the use of the said combination in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
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