公开(公告)号：EP1660085A1

公开(公告)日：2006-05-31

申请号：EP04763848.1

申请日：2004-08-06

申请人： Pharmacia Italia S.p.A.

发明人： VANOTTI, Ermes ,  D'ALESSIO, Roberto ,  TIBOLLA, Marcellino ,  VARASI, Mario ,  MONTAGNOLI, Alessia ,  SANTOCANALE, Corrado ,  MARTINA, Katia ,  MENICHINCHERI, Maria

IPC分类号： A61K31/444 ,  A61P35/00 ,  A61P25/28 ,  A61P31/12 ,  A61P37/00 ,  A61P13/08 ,  A61P17/06 ,  A61P9/10 ,  A61P11/00 ,  A61P19/02 ,  A61P13/12 ,  A61K45/06 ,  C07D519/00 ,  C07D471/04

CPC分类号： C07D471/04 ,  A61K31/444 ,  A61K31/4745 ,  A61K45/06 ,  A61K2300/00

摘要： Pyridylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

公开(公告)号：EP1622934A2

公开(公告)日：2006-02-08

申请号：EP04728359.3

申请日：2004-04-20

申请人： Pharmacia Italia S.p.A. ,  Valsasina, Barbara

发明人： VALSASINA, Barbara ,  CRISTIANI, Cinzia ,  KNAPP, Stefan ,  THIEFFINE, Sandrine ,  PEREGO, Rita ,  SACCARDO, Maria Beatrice ,  KALISZ, Henryk

IPC分类号： C07K14/47 ,  C12N15/12

CPC分类号： C07K14/4738

摘要： The present invention generally relates to the desing, expression and purification of truncated forms of the human dbf4 protein, optionally in complexe with dbf4 interacting partners, such as human cdc7, and its use in the discovery, indentification and characterization of inhibitors of the components of the complex, either when associated or when present as uncomplexed proteins in situ or in vitro. More specifically, the present invention relates to the utilization of specific truncated forms of human dbf4 for the production of an active, non-aggregated, monodispersed hetorodimer of human dbf4 complexed to human cdc7, or other protein interactors.

公开(公告)号：EP1453517B1

公开(公告)日：2006-02-08

申请号：EP02787779.4

申请日：2002-11-22

申请人： Pharmacia Italia S.p.A.

发明人： LAURIA, Sara ,  MARTINI, Alessandro ,  CIOCCA, Cristina

IPC分类号： A61K31/519 ,  A61K47/12 ,  A61P35/00

CPC分类号： A61K31/555 ,  A61K9/0019 ,  A61K31/519 ,  A61K47/12

摘要： The present invention relates to novel stable solution formulations comprising oxaliplatin, an effective stabilizing amount of lactic acid and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. A method for manufacturing such formulations ready for administration and their use in the antitumor therapy are also within the scope of the invention.

公开(公告)号：EP1599202A1

公开(公告)日：2005-11-30

申请号：EP04707538.7

申请日：2004-02-03

申请人： Pharmacia Italia S.p.A.

发明人： VANOTTI, Ermes ,  CERVI, Giovanni ,  PULICI, Maurizio ,  MENICHINCHERI, Maria ,  VARASI, Mario ,  VIANELLO, Paola ,  Ferguson, Ron.

IPC分类号： A61K31/4162 ,  C07D487/04 ,  C07D209/82 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a tetracyclic pyrazole. The invention also provides specific tetracyclic pyrazole derivatives, useful intermediates, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.

公开(公告)号：EP1390368B1

公开(公告)日：2005-10-26

申请号：EP01947360.2

申请日：2001-06-08

申请人： Pharmacia Italia S.p.A.

发明人： BARGIOTTI, Alberto ,  ERMOLI, Antonella ,  MENICHINCHERI, Maria ,  VANOTTI, Ermes ,  BONOMINI, Luisella ,  FRETTA, Antonella

IPC分类号： C07D473/18 ,  A61K31/52 ,  A61P35/00

CPC分类号： C07D473/18

摘要： The present invention relates to benzylmethyl and/or naphtylmethyl disubstituted 7,9-guaninium halides possessing antitumor activity, to pharmaceutical compositions comprising them and to a process for preparing the same. Furthermore, these compounds are expected to enhance the efficacy of other chemotherapeutic agents, in the treatment of cancer.

公开(公告)号：EP1202733B1

公开(公告)日：2005-10-05

申请号：EP00931906.2

申请日：2000-05-05

申请人： Pharmacia Italia S.p.A. ,  Pharmacia & Upjohn Company LLC

发明人： PEVARELLO, Paolo ,  ORSINI, Paolo ,  TRAQUANDI, Gabriella ,  VARASI, Mario ,  FRITZEN, Edward, L. ,  WARPEHOSKI, Martha, A. ,  PIERCE, Betsy, S. ,  BRASCA, Maria, Grabriella

IPC分类号： A61K31/415 ,  C07D231/40 ,  C07D231/16

CPC分类号： C07D403/12 ,  A61K31/415 ,  A61K31/4155 ,  A61K45/06 ,  C07D231/16 ,  C07D231/40 ,  C07D405/12 ,  C07D409/12

公开(公告)号：EP1575954A2

公开(公告)日：2005-09-21

申请号：EP03799536.2

申请日：2003-12-04

申请人： Pharmacia Italia S.p.A.

发明人： BRASCA, Maria, Gabriella ,  AMICI, Raffaella ,  FANCELLI, Daniele ,  NESI, Marcella ,  ORSINI, Paolo ,  ORZI, Fabrizio ,  ROUSSEL, Patrick ,  VULPETTI, Anna ,  PEVARELLO, Paolo

IPC分类号： C07D487/00

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10

摘要： Compounds represented by formula (Ia) or (lb) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.

公开(公告)号：EP1565576A2

公开(公告)日：2005-08-24

申请号：EP03779871.7

申请日：2003-11-07

申请人： Pharmacia Italia S.p.A.

发明人： DAZZI, Cecilia ,  ECK, Volker ,  CANTELLI, Luca ,  HARRI, Adrian ,  BRODMANN, Peter ,  SEYFARTH, Ralf

IPC分类号： C12Q1/68

CPC分类号： C12Q1/04 ,  C12Q1/689

摘要： The present invention discloses a method for the detection and identification of living microbial contaminant cells in pharmaceutical products, pharmaceutical production environments, cosmetics and food. The method of the invention is based on the selective amplification by quantitative PCR of specific target cDNA sequences, in particular sequences encoding ribosomal RNA of the microbial contaminant to be detected.The invention also provides for a test kit for the detection and identification of living microbial contaminant cells in pharmaceutical products, pharmaceutical production environments, cosmetics and food comprising primers and probes specific for a ribosomal RNA target gene of the microbial contaminant.

公开(公告)号：EP1536783A2

公开(公告)日：2005-06-08

申请号：EP03772489.5

申请日：2003-09-10

申请人： Pharmacia Italia S.p.A.

发明人： GATTI, Paolo

IPC分类号： A61K31/404 ,  A61K9/16

CPC分类号： A61K31/404 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1652

摘要： The present invention features formulations of indolinones. The formulation is suitable for parenteral or oral administration, wherein the formulation comprises an indolinone, and a pharmaceutically acceptable carrier therefor. The formulations and the compounds themselves are useful for the treatment of protein kinase related disorders.

公开(公告)号：EP1527074A1

公开(公告)日：2005-05-04

申请号：EP03738125.8

申请日：2003-07-16

申请人： Pharmacia Italia S.p.A.

发明人： VILLA, Manuela ,  ABRATE, Francesca ,  FANCELLI, Daniele ,  VARASI, Mario ,  VULPETTI, Anna

IPC分类号： C07D487/04 ,  A61K31/415 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/415 ,  A61K45/06 ,  C07D471/04 ,  A61K2300/00

摘要： The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a pyrrolo-pyrazole or pyrazolo-azepine. The invention also provides specific pyrrolo-pyrazoles and pyrazolo-azepines, useful intermediates, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.