发明公开
EP1300396A1 1,2-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF
有权
1,2-DIHYDROPRIDINVERBINDUNGEN，VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG
- 专利标题： 1,2-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF
- 专利标题（中）： 1,2-DIHYDROPRIDINVERBINDUNGEN，VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG
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申请号： EP01936920.6申请日： 2001-06-08
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公开(公告)号： EP1300396A1公开(公告)日： 2003-04-09
- 发明人: NAGATO, Satoshi , UENO, Kohshi , KAWANO, Koki , NORIMINE, Yoshihiko , ITO, Koichi , HANADA, Takahisa , UENO, Masataka , AMINO, Hiroyuki , OGO, Makoto , HATAKEYAMA, Shinji , URAWA, Yoshio , NAKA, Hiroyuki , GROOM, Anthony, John , RIVERS, Leanne , SMITH, Terence
- 申请人： Eisai Co., Ltd.
- 申请人地址： 6-10, Koishikawa 4-chome, Bunkyo-ku Tokyo 112-8088 JP
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： 6-10, Koishikawa 4-chome, Bunkyo-ku Tokyo 112-8088 JP
- 代理机构： Cornish, Kristina Victoria Joy
- 优先权： JP2000175966 20000612; GB0022483 20000913
- 国际公布： WO01096308 20011220
- 主分类号： C07D213/71
- IPC分类号： C07D213/71
摘要：
The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof.
In the formula, Q indicates NH, O or S; and R 1 , R 2 , R 3 , R 4 and R 5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C 1-6 alkyl group or a group represented by the formula -X-A (wherein X indicates a single bond, an optionally sbutituted C 1-6 alkylene group etc.; and A indicates an optionally substituted C 6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
In the formula, Q indicates NH, O or S; and R 1 , R 2 , R 3 , R 4 and R 5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C 1-6 alkyl group or a group represented by the formula -X-A (wherein X indicates a single bond, an optionally sbutituted C 1-6 alkylene group etc.; and A indicates an optionally substituted C 6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
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