发明公开
EP1301541A2 BIFUNCTIONAL MOLECULES AND VECTORS COMPLEXED THEREWITH FOR TARGETED GENE DELIVERY
审中-公开
双功能分子和有针对性的复合SO基因递送载体
- 专利标题： BIFUNCTIONAL MOLECULES AND VECTORS COMPLEXED THEREWITH FOR TARGETED GENE DELIVERY
- 专利标题（中）： 双功能分子和有针对性的复合SO基因递送载体
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申请号： EP01955340.3申请日： 2001-07-09
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公开(公告)号： EP1301541A2公开(公告)日： 2003-04-16
- 发明人: NEMEROW, Glen, R. , LI, Erguang
- 申请人： Novartis AG , Novartis-Erfindungen Verwaltungsgesellschaft m.b.H. , The Scripps Research Institute
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： Novartis AG,Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.,The Scripps Research Institute
- 当前专利权人： Novartis AG,Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.,The Scripps Research Institute
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： Gros, Florent
- 优先权： US613017 20000710
- 国际公布： WO02004522 20020117
- 主分类号： C07K19/00
- IPC分类号： C07K19/00 ; C12N15/62 ; A61K48/00 ; C07K16/28 ; C07K14/525 ; C07K14/475 ; C07K14/485 ; C07K14/65 ; C12N15/861
摘要：
Methods and products for targeting delivery vectors, such as adenoviral gene delivery particles, to selected cell types are provided. The methods rely on targeting by a bifunctional molecule that specifically complexes with a protein on the vector particle surface and with targeted cell surface proteins. The targeted cell surface proteins are any that activate the phosphatidylinositol-3-OH kinases. The bifunctional molecules, compositions, kits, and methods of preparation and use of the vector/bifunctional molecules for gene therapy are provided.
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