公开(公告)号：EP1324652B1

公开(公告)日：2007-04-18

申请号：EP01974319.4

申请日：2001-10-01

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： COHEN, Dalia ,  DENGLER, Uwe, Jochen ,  FINELLI, Alyce, Lynn ,  FREULER, Felix ,  KONSOLAKI, Mary ,  REINHARDT, Mischa, Werner, Henri, Marie ,  ZUSMAN, Susan

IPC分类号： A01K67/033 ,  C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  C12N15/11 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  A61K48/00 ,  A61K39/395 ,  A61K38/00

CPC分类号： C07K14/4711 ,  A01K67/0339 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505

摘要： Transgenic files displaying altered phenotypes due to expression of the Abeta and C99 portions of the human APP gene are disclosed. Use of these files in a method to identify Drosophila genes and the human homologs of these Drosophila genes, that are potentially involved in Alzheimer's Disease, is also disclosed. The use of said human homologs as drug targets for the development of therapeutics to treat Alzheimer's Disease and other conditions associated with defects in the APP pathway, as well as pharmaceutical compositions comprising substances directed to these genes, are also disclosed.

公开(公告)号：EP1343790B1

公开(公告)日：2006-03-01

申请号：EP01997475.7

申请日：2001-11-20

申请人： SANDOZ AG

发明人： BERGER, Andres ,  DECRISTORFORO, Martin ,  LUDESCHER, Johannes ,  SCHLEICH, Herbert

IPC分类号： C07D501/36

CPC分类号： C07D501/00

摘要： Ceftiofur in the form of a sodium salt which is practically free of organic solvent and a process for its production.

公开(公告)号：EP1281400B1

公开(公告)日：2005-11-23

申请号：EP02023033.0

申请日：1996-07-12

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： Guitard, Patrice ,  Haeberlin, Barbara ,  Link, Rainer ,  Richter, Friedrich

IPC分类号： A61K31/445 ,  A61K9/14 ,  A61K47/48

CPC分类号： A61K31/4745 ,  A61K9/145 ,  A61K9/146 ,  A61K31/436 ,  A61K31/445 ,  Y10S514/885 ,  Y10S514/922 ,  Y10S514/95 ,  Y10S514/964 ,  Y10S514/97

公开(公告)号：EP1252222B1

公开(公告)日：2005-11-09

申请号：EP01919255.8

申请日：2001-02-02

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： WINTERTON, Lynn, Cook ,  LALLY, John, Martin ,  RUBNER, Michael, F. ,  QIU, Yongxing

IPC分类号： C08J7/04 ,  A61L27/34 ,  A61L27/40 ,  A61L27/44 ,  G02B1/04 ,  B05D1/18

CPC分类号： G02B1/043 ,  A61L27/34 ,  B05D1/185 ,  B05D7/52 ,  C08J7/04 ,  C08J2375/04

公开(公告)号：EP1307227B1

公开(公告)日：2005-11-02

申请号：EP01971777.6

申请日：2001-07-24

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BRUNO-RAIMONDI, Alfredo, Emilio

IPC分类号： A61K41/00 ,  A61P31/00

CPC分类号： A61K41/0042 ,  A61K41/00 ,  A61K41/0019 ,  A61K31/495 ,  A61K31/415 ,  A61K31/41 ,  A61K31/135 ,  A61K2300/00

摘要： A method for the topical treatment of nail diseases, e.g. onychomycosis, after preparation of the infected nail with a laser beam.

公开(公告)号：EP1252196B1

公开(公告)日：2005-11-02

申请号：EP01915126.5

申请日：2001-01-03

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： DOMSCHKE, Angelika, Maria ,  FRANCIS, Vimala, Mary

IPC分类号： C08F2/10 ,  C08F2/48 ,  G02B1/04

CPC分类号： C08J9/26 ,  A61L27/16 ,  A61L27/56 ,  C08F2/06 ,  C08F2/44 ,  C08J2201/0462 ,  C08J2300/00 ,  G02B1/043

摘要： The present invention relates to a process for the manufacture of a porous polymer, wherein a composition comprising a polymerizable component, a porogen having an inverse temperature dependent solubility and a solvent are polymerized at a temperature around the cloud point temperature of the composition. The porous polymers obtainable according to the process of the invention are useful, for example, as materials for the manufacture of biomedical devices and prostheses, including ophthalmic devices such as contact lenses or artificial corneas.

公开(公告)号：EP1292598B1

公开(公告)日：2005-09-28

申请号：EP01943455.4

申请日：2001-05-28

申请人： SANDOZ AG

发明人： BILKE, Hans, Werner ,  DAEMON, Otto ,  SCHWARZ, Franz, Xaver

IPC分类号： C07D499/00 ,  A61K31/43

CPC分类号： C07D499/00 ,  A61K9/2095 ,  A61K31/43

摘要： Process for drying amoxicillin (compositions), characterised in that a gas, which is inert towards amoxicillin (compositions) and having a relative humidity content which is greater than zero is used for drying.

公开(公告)号：EP1278754B1

公开(公告)日：2005-01-26

申请号：EP01933896.1

申请日：2001-04-26

申请人： SANDOZ AG

发明人： KREMMINGER, Peter ,  LUDESCHER, Johannes ,  WOLF, Siegfried

IPC分类号： C07D501/04 ,  C07D277/46 ,  C07D501/36

CPC分类号： C07D501/00 ,  C07D277/46

摘要： A process and intermediates in the production of cefotiam (hexetil).

公开(公告)号：EP1244359B1

公开(公告)日：2005-01-12

申请号：EP00985086.8

申请日：2000-11-23

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BOUVIER, Jacques ,  KOLLY, Catherine

IPC分类号： A01N43/90

CPC分类号： A01N47/34 ,  A01N43/90 ,  A01N2300/00

摘要： An active ingredient combination for the simultaneous control of ecto- and endoparasites, especially mites, ticks and nematodes, on productive livestock, domestic animals and pets, is described, which comprises the active ingredients (1) 1-[4-chloro-3-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl]-3-(2,6-difluorobenzoyl)urea and (2) a compound of formula (i) wherein R1 is hydrogen or one of radicals (ii) or (iii), R2 is CH(CH3)-CH3, -CH(CH3)-C2H5, -C(CH3)=CH-CH(CH3)2 or cyclohexyl; R3 is hydrogen or hydroxy if the bond between atoms 22 and 23 represents a double bond, or is hydrogen or the group =N-O-CH3 if a single bond is present between atoms 22 and 23; and R4 is HO- or HO-N=, in free form or in the form of a physiologically acceptable salt.

公开(公告)号：EP1276510B1

公开(公告)日：2004-09-29

申请号：EP01931618.1

申请日：2001-04-18

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： SCHERER, Anton ,  SCHWIND, Peter

IPC分类号： A61L12/08 ,  A61L12/12 ,  A61L12/14

CPC分类号： A61K35/748 ,  A61L12/082 ,  A61L12/126 ,  A61L12/14 ,  Y10S134/901

摘要： The present invention is directed to an ophthalmic product comprising, as a colouring agent, the extract of an alga. A preferred class of alga the extract of which is useful in the present invention is blue alga (Spirulina type), more preferred it is Japanese blue alga (Spirulina platensis). The ophthalmic product is preferably a contact lens care product.