发明公开
- 专利标题： A PROCESS FOR THE PREPARATION OF $g(a)' CHLOROKETONES
- 专利标题（中）： 用于生产的α“氯酮
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申请号： EP01961698.6申请日： 2001-07-20
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公开(公告)号： EP1309535A1公开(公告)日： 2003-05-14
- 发明人: KRONENTHAL, David , SCHWINDEN, Mark, D.
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： P.O. Box 4000 Princeton, NJ 08540-4000 US
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址： P.O. Box 4000 Princeton, NJ 08540-4000 US
- 代理机构： Howard, Paul Nicholas
- 优先权： US225711P 20000816
- 国际公布： WO02014256 20020221
- 主分类号： C07C45/61
- IPC分类号： C07C45/61 ; C07D301/00 ; C07D301/24
摘要：
The present invention relates to a process for the preparation of α' chloroketones, such as 4-phenyl-3-t-butyloxy-carbonylamino)-2-keto-1-chlorobutane by reacting certain aryl amino acid esters, e.g. N-(2-t-butoxycarbonyl)-L-phenylalanine-4-nitrophenyl ester, with a sulfur ylide compound to form the corresponding keto ylide compound which is then treated with a source of chloride and an organic acid.
公开/授权文献
- EP1309535B1 A PROCESS FOR THE PREPARATION OF ALPHA'-CHLOROKETONES 公开/授权日：2008-03-26
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