专利检索 ap:("BRISTOL-MYERS SQUIBB COMPANY") AND inv:"KRONENTHAL, David" 第 1 页

1.

发明公开
A PROCESS FOR THE PREPARATION OF $g(a)' CHLOROKETONES 有权
标题翻译：用于生产的α“氯酮

公开(公告)号：EP1309535A1

公开(公告)日：2003-05-14

申请号：EP01961698.6

申请日：2001-07-20

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： KRONENTHAL, David , SCHWINDEN, Mark, D.

IPC分类号： C07C45/61 , C07D301/00 , C07D301/24

CPC分类号： C07C269/06 , C07C221/00 , C07D303/36 , C07C271/18

摘要： The present invention relates to a process for the preparation of α' chloroketones, such as 4-phenyl-3-t-butyloxy-carbonylamino)-2-keto-1-chlorobutane by reacting certain aryl amino acid esters, e.g. N-(2-t-butoxycarbonyl)-L-phenylalanine-4-nitrophenyl ester, with a sulfur ylide compound to form the corresponding keto ylide compound which is then treated with a source of chloride and an organic acid.

2.

发明授权
A PROCESS FOR THE PREPARATION OF ALPHA'-CHLOROKETONES 有权
标题翻译：用于生产的α“氯酮

公开(公告)号：EP1309535B1

公开(公告)日：2008-03-26

申请号：EP01961698.6

申请日：2001-07-20

申请人： Bristol-Myers Squibb Company

发明人： KRONENTHAL, David , SCHWINDEN, Mark, D.

IPC分类号： C07C45/61 , C07D301/00 , C07D301/24

CPC分类号： C07C269/06 , C07C221/00 , C07D303/36 , C07C271/18

摘要： The present invention relates to a process for the preparation of α' chloroketones, such as 4-phenyl-3-t-butyloxy-carbonylamino)-2-keto-1-chlorobutane by reacting certain aryl amino acid esters, e.g. N-(2-t-butoxycarbonyl)-L-phenylalanine-4-nitrophenyl ester, with a sulfur ylide compound to form the corresponding keto ylide compound which is then treated with a source of chloride and an organic acid.