发明公开
EP1310486A4 PROCESS FOR PRODUCING 5-FLUOROOXYINDOLE AND FOR PRODUCING INTERMEDIATE THEREFOR
审中-公开
工艺进行生产5 FLUOROXYINDOL并生产中间体
- 专利标题： PROCESS FOR PRODUCING 5-FLUOROOXYINDOLE AND FOR PRODUCING INTERMEDIATE THEREFOR
- 专利标题（中）： 工艺进行生产5 FLUOROXYINDOL并生产中间体
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申请号： EP01951925申请日： 2001-07-19
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公开(公告)号： EP1310486A4公开(公告)日： 2005-07-27
- 发明人: HARADA KATSUMASA , NISHINO SHIGEYOSHI , HIROTSU KENJI , YOKOYAMA SHUJI , TAKAHASHI TAKESHI , ODA HIROYUKI
- 申请人： UBE INDUSTRIES
- 专利权人： UBE INDUSTRIES
- 当前专利权人： UBE INDUSTRIES
- 优先权： JP2000219161 2000-07-19; JP2000239655 2000-08-08; JP2000327345 2000-10-26
- 主分类号： C07C205/56
- IPC分类号： C07C205/56 ; C07C255/41 ; C07D209/32 ; C07D209/34 ; C07C201/12 ; C07C205/26 ; C07C253/30 ; C07D209/42
摘要：
A process for producing 5-fluorooxyindole, represented by the formula (3) characterized by comprising (A) a first step in which a 2-(5-fluoro-2-nitrophenyl)malonic diester represented by the general formula (1) (wherein R?1 and R2¿ may be the same or different and each represents a group not participating in reactions) is cyclized under reduction conditions to generate a 5-fluorooxyindole-3-carboxylic ester represented by the general formula (2) (wherein R1 is the same as defined above) and (B) a second step in which the 5-fluorooxyindole-3-carboxylic ester is decarboxylated.
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