公开(公告)号：EP2123627A4

公开(公告)日：2010-07-21

申请号：EP07707070

申请日：2007-01-19

申请人： UBE INDUSTRIES

发明人： NISHINO SHIGEYOSHI ,  SHIMA HIDETAKA ,  ODA HIROYUKI

IPC分类号： C07C213/02 ,  C07B61/00 ,  C07C217/86 ,  C07C219/34 ,  C07D213/73

CPC分类号： C07D213/73 ,  C07C213/02 ,  C07C217/86

公开(公告)号：EP1310486A4

公开(公告)日：2005-07-27

申请号：EP01951925

申请日：2001-07-19

申请人： UBE INDUSTRIES

发明人： HARADA KATSUMASA ,  NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  YOKOYAMA SHUJI ,  TAKAHASHI TAKESHI ,  ODA HIROYUKI

IPC分类号： C07C205/56 ,  C07C255/41 ,  C07D209/32 ,  C07D209/34 ,  C07C201/12 ,  C07C205/26 ,  C07C253/30 ,  C07D209/42

CPC分类号： C07D209/34 ,  C07C201/12 ,  C07C205/56 ,  C07C255/41 ,  C07D209/32

摘要： A process for producing 5-fluorooxyindole, represented by the formula (3) characterized by comprising (A) a first step in which a 2-(5-fluoro-2-nitrophenyl)malonic diester represented by the general formula (1) (wherein R?1 and R2¿ may be the same or different and each represents a group not participating in reactions) is cyclized under reduction conditions to generate a 5-fluorooxyindole-3-carboxylic ester represented by the general formula (2) (wherein R1 is the same as defined above) and (B) a second step in which the 5-fluorooxyindole-3-carboxylic ester is decarboxylated.

公开(公告)号：EP1661894A4

公开(公告)日：2007-02-28

申请号：EP04747476

申请日：2004-07-14

申请人： UBE INDUSTRIES

发明人： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  IWAMOTO KEIJI ,  HARADA TAKASHI ,  SUZUKI SHINOBU

IPC分类号： C07D309/14 ,  C07B61/00 ,  C07D309/10

CPC分类号： C07D309/10 ,  C07D309/14

摘要： A process for the production of 4-aminotetrahydropyrans represented by the general formula (2) and salts thereof with acids: [wherein R is hydrogen or a hydrocarbon group], characterized by subjecting a 4-hydrazinotetrahydropyran represented by the general formula (1) or a salt thereof with an acid: [wherein R is as defined above] to decomposition in the presence of at least one compound selected from among Raney nickel, noble metal catalysts, and metal oxides; intermediates for the process; and a process for the production of the intermediates.

公开(公告)号：EP1650196A4

公开(公告)日：2007-02-28

申请号：EP04748126

申请日：2004-07-30

申请人： UBE INDUSTRIES

发明人： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  ODA HIROYUKI ,  SUZUKI SHINOBU

IPC分类号： C07D239/88 ,  C07C67/31

CPC分类号： C07D239/88 ,  C07C67/31 ,  C07C69/92

摘要： [PROBLEMS] A process for obtaining 6,7-bis(2-methoxyethoxy)­quinazolin-4-one in a high yield from ethyl 2-amino-4,5­bis(2-methoxyethoxy)benzoate. [MEANS FOR SOLVING PROBLEMS] The process for producing 6,7-bis(2-methoxyethoxy)quinazolin-4-one comprises reacting ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate with a formic acid compound in the presence of an ammonium carboxylate.

公开(公告)号：EP1674451A4

公开(公告)日：2006-12-06

申请号：EP04787799

申请日：2004-09-09

申请人： UBE INDUSTRIES

发明人： NISHINO SHIGEYOSHI ,  SHIKITA SHOJI ,  OMATA YOJI

IPC分类号： C07C259/06

CPC分类号： C07C259/06

摘要： A method for producing N,N'-dialkoxy-N,N'-dialkyl oxamide represented by the general formula (3): wherein R and R are as defined below, is characterized in that an oxalate diester represented by the general formula (1): wherein R and R may be the same or different and respectively represent a hydrocarbon group, is reacted with N-alkyl-O-alkylhydroxylamine represented by the general formula (2): R O

摘要翻译： 由通式（3）表示的N，N'-二烷氧基-N，N'-二烷基草酰胺的制备方法：其中R 2和R 3如下所定义，其特征在于所代表的草酸二酯 （1）表示：其中R 1和R 1'可以相同或不同并且分别表示烃基，与通式（2）表示的N-烷基-O-烷基羟胺 ：R 2 O.

公开(公告)号：EP1927590A4

公开(公告)日：2010-05-12

申请号：EP06796645

申请日：2006-08-22

申请人： UBE INDUSTRIES

发明人： NISHINO SHIGEYOSHI ,  YOKOYAMA SHUJI ,  ODA HIROYUKI ,  OMATA YOJI ,  TAKIGAWA SHINYA

IPC分类号： C07D233/64

CPC分类号： C07D233/64

公开(公告)号：EP1251123A4

公开(公告)日：2003-02-05

申请号：EP01901537

申请日：2001-01-24

申请人： UBE INDUSTRIES ,  NISSAN CHEMICAL IND LTD

发明人： HARADA KATSUMASA ,  NISHINO SHIGEYOSHI ,  OKADA NAOKO ,  SHIMA HIDETAKA ,  HARADA TAKASHI

IPC分类号： C07D215/12 ,  C07D215/14

CPC分类号： C07D215/12

摘要： 3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enenitrile is prepared by reacting 2-cyclopropyl-4- (4-fluorophenyl)quinoline-3-carbaldehyde with acetonitrile in the presence of a base and then adding a dehydrating agent to the reaction mixture to conduct dehydration. Under ordinary conditions, novel 3-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3-hydroxypropionitrile is formed as an intermediate in the above reaction. Incidentally, when the above reaction is conducted in an organic solvent, 3-[2- cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enenitrile is directly formed.

公开(公告)号：EP0922704A4

公开(公告)日：2002-01-02

申请号：EP97936857

申请日：1997-08-22

申请人： NIPPON CHEMIPHAR CO ,  UBE INDUSTRIES

发明人： YAMAMOTO MASAO ,  KOBAYASHI KUNIO ,  HARADA KATSUMASA ,  NISHINO SHIGEYOSHI ,  SASAKI HIROSHI

IPC分类号： C07D337/14 ,  C07C205/56 ,  C07C229/40 ,  C07C323/62 ,  C07C229/42 ,  C07C233/11 ,  C07C255/41

CPC分类号： C07D337/14

摘要： A novel process for preparing zaltoprofen[2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid], which, as compared with the conventional processes, has better practicality from an overall viewpoint including availability and handleability of a starting material and profitability, such as the yield. The novel process is characterized by providing 2-(4-amino-3-carboxymethylphenyl)propionic acid or a salt thereof as a starting compound, subjecting the starting compound to, e.g., diazotization reacting the diazotized compound with thiophenol to prepare 2-(3-carboxymethyl-4-phenylthiophenyl)propionic acid or a salt thereof, and then subjecting this product to a ring-closing reaction. Intermediate compounds useful for the preparation of the above compound are also provided.

公开(公告)号：EP3064489A4

公开(公告)日：2017-06-21

申请号：EP14857120

申请日：2014-11-04

申请人： UBE INDUSTRIES

发明人： NISHINO SHIGEYOSHI ,  SHIMA HIDETAKA ,  ODA HIROYUKI ,  SHIMANO TETSURO

IPC分类号： C07C381/00 ,  A61K31/167 ,  A61K31/216 ,  A61K31/36 ,  A61P1/02 ,  A61P3/06 ,  A61P3/10 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61P19/02 ,  A61P19/10 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P35/04

CPC分类号： C07C381/00 ,  A61K31/167 ,  A61K31/216 ,  A61K31/36 ,  C07D207/327 ,  C07D207/34 ,  C07D213/81 ,  C07D213/82 ,  C07D231/12 ,  C07D231/14 ,  C07D233/90 ,  C07D237/24 ,  C07D239/28 ,  C07D239/34 ,  C07D241/24 ,  C07D263/34 ,  C07D277/56 ,  C07D307/68 ,  C07D311/16 ,  C07D317/60 ,  C07D333/38

摘要： Provided is an aryloyl(oxy or amino)pentafluorosulfanylbenzene compound having pharmacological action. The present invention relates to an aryloyl(oxy or amino)pentafluorosulfanylbenzene compound represented by general formula (A-I), a pharmaceutically acceptable salt thereof, and a prodrug thereof; wherein all of parameters represent the same meanings as defined in the specification.

摘要翻译： 提供具有药理作用的芳酰基（氧或氨基）五氟硫烷基苯化合物。 本发明涉及由通式（A-I）表示的芳酰基（氧或氨基）五氟硫烷基苯化合物，其药学上可接受的盐及其前药; 其中所有参数表示与说明书中定义的相同的含义。

公开(公告)号：EP1352898A4

公开(公告)日：2005-07-20

申请号：EP01272314

申请日：2001-12-25

申请人： UBE INDUSTRIES

发明人： HARADA KATSUMASA ,  NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  NAKAMURA AKIRA ,  HARADA TAKASHI

IPC分类号： C07C253/30 ,  C07C255/17 ,  C07C255/31

CPC分类号： C07C253/30 ,  C07C2601/02 ,  C07C255/17 ,  C07C255/31

摘要： A process comprising reacting an aliphatic carboxylic ester compound with acetonitrile in the presence of a metal alkoxide to yield a metal salt of a β-ketonitrile compound, subsequently transferring the salt to an aqueous medium, and neutralizing the solution to obtain the β-Ketonitrile compound in a free state, wherein a water-incompatible organic solvent and water are added to the reaction mixture containing the β-Ketonotrile compound metal salt yielded to transfer the metal salt to the water, the resultant aqueous solution of the β-Ketonitrile compound metal salt is separated from the organic solvent by phase separation or another technique and then neutralized, and the resultant free β- Ketonitrile compound is taken out by extraction with an organic solvent.

摘要翻译： 在金属醇盐存在下，使脂肪族羧酸酯化合物与乙腈反应，生成β-酮腈化合物的金属盐后，将其转移到水性介质中，中和该溶液，得到β-酮腈化合物 在游离状态下，向含有β-酮化合物金属盐的反应混合物中加入水不相容有机溶剂和水，将所得金属盐转移到水中，得到的β-酮腈化合物金属盐水溶液 通过相分离或其他技术从有机溶剂中分离出来，然后中和，并且通过用有机溶剂萃取而将所得的游离β-乙腈化合物取出。