发明授权
- 专利标题： MAUROTOXIN, PI1 AND HSTX1 DERIVATIVES
- 专利标题（中）： MAURO毒素，PI1及其衍生物HsTX1
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申请号： EP01980332.9申请日： 2001-09-03
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公开(公告)号： EP1315747B1公开(公告)日： 2006-03-29
- 发明人: SABATIER, Jean-Marc , MABROUK, Kamel , ROCHAT, Hervé
- 申请人： Cellpep S.A.
- 申请人地址： 16, rue de la Banque 75002 Paris FR
- 专利权人： Cellpep S.A.
- 当前专利权人： Cellpep S.A.
- 当前专利权人地址： 16, rue de la Banque 75002 Paris FR
- 代理机构： McKelvey, Ian Edward
- 优先权： GB0021639 20000904; GB0024538 20001006
- 国际公布： WO2002020596 20020314
- 主分类号： C07K14/435
- IPC分类号： C07K14/435 ; A61K38/17 ; A01N63/02
摘要：
Derivatives of Maurotoxin (MTX) in which the native disulfide bridge pattern (Cys3-Cys24, Cys9-Cys29, Cys19, Cys31-Cys34) has been disrupted are useful for the treatment of pathologies associated with dysfunctioning and/or activation of Ca -activated and/or voltage-gated K channel subtypes, such as IKCa1 or Kv1.2. One preferred group of derivatives is that in which one or more of the Cys residues have been replaced with
公开/授权文献
- EP1315747A2 MAUROTOXIN, PI1 AND HSTX1 DERIVATIVES 公开/授权日：2003-06-04
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