发明授权
- 专利标题： AMIDINE INHIBITORS OF SERINE PROTEASES
- 专利标题（中）： 丝氨酸蛋白酶抑制剂的脒
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申请号： EP01968579.1申请日： 2001-09-05
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公开(公告)号： EP1317429B1公开(公告)日： 2006-08-30
- 发明人: PASTOR, Richard, M. , ARTIS, Dean, R. , OLIVERA, Alan, G.
- 申请人： Genentech Inc.
- 申请人地址： 1 DNA Way South San Francisco, CA 94080-4990 US
- 专利权人： Genentech Inc.
- 当前专利权人： Genentech Inc.
- 当前专利权人地址： 1 DNA Way South San Francisco, CA 94080-4990 US
- 代理机构： Barz, Peter
- 优先权： US231679P 20000911
- 国际公布： WO2002022575 20020321
- 主分类号： C07D207/16
- IPC分类号： C07D207/16 ; C07D401/06 ; C07D403/12 ; C07D207/48 ; C07D401/12 ; A61K31/40 ; A61K31/401 ; A61K31/4025 ; A61P7/02
摘要：
Inhibitors of serine proteases are provided having formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein. In particular, the compounds bind to factor VIIa, tissue factor/factor Xa complex, thrombin, trypsin, plasmin and kallikrein and have anticoagulant activity. Pharmaceutical compositions comprising the compounds are useful for inhibiting the formation of veinous and/or arterial thrombi in vivo.
公开/授权文献
- EP1317429A1 AMIDINE INHIBITORS OF SERINE PROTEASES 公开/授权日：2003-06-11
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