公开(公告)号：EP1317429B1

公开(公告)日：2006-08-30

申请号：EP01968579.1

申请日：2001-09-05

申请人： Genentech Inc.

发明人： PASTOR, Richard, M. ,  ARTIS, Dean, R. ,  OLIVERA, Alan, G.

IPC分类号： C07D207/16 ,  C07D401/06 ,  C07D403/12 ,  C07D207/48 ,  C07D401/12 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4025 ,  A61P7/02

CPC分类号： C07D401/06 ,  C07D207/16 ,  C07D207/48 ,  C07D401/12 ,  C07D403/12

摘要： Inhibitors of serine proteases are provided having formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein. In particular, the compounds bind to factor VIIa, tissue factor/factor Xa complex, thrombin, trypsin, plasmin and kallikrein and have anticoagulant activity. Pharmaceutical compositions comprising the compounds are useful for inhibiting the formation of veinous and/or arterial thrombi in vivo.

公开(公告)号：EP1317429A1

公开(公告)日：2003-06-11

申请号：EP01968579.1

申请日：2001-09-05

申请人： Genentech Inc.

发明人： PASTOR, Richard, M. ,  ARTIS, Dean, R. ,  OLIVERA, Alan, G.

IPC分类号： C07D207/16 ,  C07D401/06 ,  C07D403/12 ,  C07D207/48 ,  C07D401/12 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4025 ,  A61P7/02

CPC分类号： C07D401/06 ,  C07D207/16 ,  C07D207/48 ,  C07D401/12 ,  C07D403/12

摘要： Inhibitors of serine proteases are provided having formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein. In particular, the compounds bind to factor VIIa, tissue factor/factor Xa complex, thrombin, trypsin, plasmin and kallikrein and have anticoagulant activity. Pharmaceutical compositions comprising the compounds are useful for inhibiting the formation of veinous and/or arterial thrombi in vivo.