发明公开
- 专利标题： PIPERAZIN-2-ONE AMIDES AS INHIBITORS OF FACTOR XA
- 专利标题（中）： 哌嗪2 ONAMIDE AS Xa因子抑制剂
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申请号： EP01979304.1申请日： 2001-10-01
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公开(公告)号： EP1322643A1公开(公告)日： 2003-07-02
- 发明人: ZHU, Bing-Yan , SU, Ting , LI, Wenhao , GOLDMAN, Erick, A. , ZHANG, Penglie , JIA, Zhaozhong, Jon , SCARBOROUGH, Robert, M.
- 申请人： Millennium Pharmaceuticals, Inc.
- 申请人地址： 256 E. Grand Avenue South San Francisco CA 94080 US
- 专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： 256 E. Grand Avenue South San Francisco CA 94080 US
- 代理机构： Thomson, Paul Anthony
- 优先权： US236393P 20000929
- 国际公布： WO02026734 20020404
- 主分类号： C07D409/12
- IPC分类号： C07D409/12 ; C07D409/14 ; C07D241/08 ; C07D403/10 ; C07D401/14 ; C07D491/113 ; C07D401/12 ; C07D405/14 ; A61K31/495 ; A61P7/02
摘要：
Novel piperazin-2-one containing compounds of general formulae (I) or (II), including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivative having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
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