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公开(公告)号：EP1373194A1
公开(公告)日：2004-01-02
申请号：EP02726698.0
申请日：2002-04-01
发明人： ZHU, Bin-Yan , ZHANG, Penglie , GOLDMAN, Erick, A. , JIA, Zhaozhing, Jon , BAUER, Shawn , HUANG, Wenrong , WOOLFREY, John , SCARBOROUGH, Robert, M.
IPC分类号： C07C257/18 , C07C279/18 , C07D213/46 , C07D213/53 , C07D333/20 , C07D333/38 , A61K31/44 , A61K31/38 , A61P7/02
CPC分类号： C07D213/75 , C07C237/42 , C07C255/57 , C07C257/18 , C07D205/04 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/62 , C07D233/22 , C07D233/64 , C07D295/13 , C07D295/195 , C07D307/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , G02B6/2746
摘要： Novel benzamide compounds of formula (I), their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders wherein: Ar1, Ar2 and Ar3 are each independently selected from the group consisting of formula (II).
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公开(公告)号：EP1216228A2
公开(公告)日：2002-06-26
申请号：EP00963452.8
申请日：2000-09-15
发明人： ZHU, Bing-Yan , ZHANG, Penglie , WANG, Lingyan , HUANG, Wenrong , GOLDMAN, Eric , LI, Wenhao , ZUCKETT, Jingmei , SONG, Yonghong , SCARBOROUGH, Robert
IPC分类号： C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D417/12 , A61K31/18 , A61K31/33 , A61P7/02
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：EP1259485B1
公开(公告)日：2005-11-30
申请号：EP01918257.5
申请日：2001-02-28
发明人： ZHU, Bing-Yan , ZHANG, Penglie , WANG, Lingyan , HUANG, Wenrong , GOLDMAN, Erick , LI, Wenhao , ZUCKETT, Jingmei , SONG, Yonghong , SCARBOROUGH, Robert
IPC分类号： C07D213/75 , C07D401/12 , A61K31/44 , A61P7/02
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described Compositions containing such compounds are also described The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders
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公开(公告)号：EP1259485A2
公开(公告)日：2002-11-27
申请号：EP01918257.5
申请日：2001-02-28
发明人： ZHU, Bing-Yan , ZHANG, Penglie , WANG, Lingyan , HUANG, Wenrong , GOLDMAN, Erick , LI, Wenhao , ZUCKETT, Jingmei , SONG, Yonghong , SCARBOROUGH, Robert
IPC分类号： C07D213/75 , C07D401/12 , A61K31/44 , A61P7/02
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described Compositions containing such compounds are also described The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders
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5.发明授权
公开(公告)号：EP1678161B1
公开(公告)日：2009-12-30
申请号：EP04794320.4
申请日：2004-10-05
IPC分类号： C07D213/75 , C07D401/12 , A61K31/435 , A61P7/02
CPC分类号： C07D213/75 , C04B35/632 , C07D401/12
摘要： Thioether-substituted benzamide compounds having the formula: are provided that exhibit exceptionally strong inhibition of Factor Xa in combination with weak hERG binding.
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6.发明公开
公开(公告)号：EP1678161A2
公开(公告)日：2006-07-12
申请号：EP04794320.4
申请日：2004-10-05
IPC分类号： C07D401/12
CPC分类号： C07D213/75 , C04B35/632 , C07D401/12
摘要： Thioether-substituted benzamide compounds having the formula: are provided that exhibit exceptionally strong inhibition of Factor Xa in combination with weak hERG binding.
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公开(公告)号：EP1322637A2
公开(公告)日：2003-07-02
申请号：EP01979305.8
申请日：2001-10-01
发明人： ZHU, Bing-Yan , HUANG, Wenrong , ZHANG, Penglie , JIA, Zhaozhong, Jon , BAO, Liang , WU, Yanhong , SCARBOROUGH, Robert, M.
IPC分类号： C07D401/14 , C07D401/12 , C07D213/75 , A61K31/44 , A61K31/4427 , A61P7/02
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14
摘要： Novel quaternary amidino-containing compounds of the general formulae (I), (II), (III), (IV), (V) and (VI): including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
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公开(公告)号：EP1322610A2
公开(公告)日：2003-07-02
申请号：EP01975505.7
申请日：2001-10-01
发明人： ZHU, Bing-Yan , JIA, Zhaozhong, Jon , ZHANG, Penglie , HUANG, Wenrong , WU, Yanhong , ZUCKETT, Jingmei, Fan , GOLDMAN, Erik, A. , WANG, Lingyan , SONG, Yonghong , SCARBOROUGH, Robert, M.
IPC分类号： C07D209/30
CPC分类号： C07D239/06 , C07D205/04 , C07D209/30 , C07D233/06 , C07D295/26 , C07D333/62 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14
摘要： Novel compounds of the general formulae (I) or (II), including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
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公开(公告)号：EP1373194B1
公开(公告)日：2007-08-01
申请号：EP02726698.0
申请日：2002-04-01
发明人： ZHU, Bin-Yan , ZHANG, Penglie , GOLDMAN, Erick, A. , JIA, Zhaozhing, Jon , BAUER, Shawn , HUANG, Wenrong , WOOLFREY, John , SCARBOROUGH, Robert, M.
IPC分类号： C07C257/18 , C07C279/18 , C07D213/46 , C07D213/53 , C07D333/20 , C07D333/38 , A61K31/44 , A61K31/38 , A61P7/02
CPC分类号： C07D213/75 , C07C237/42 , C07C255/57 , C07C257/18 , C07D205/04 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/62 , C07D233/22 , C07D233/64 , C07D295/13 , C07D295/195 , C07D307/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , G02B6/2746
摘要： Novel benzamide compounds of formula (I), their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders wherein: Ar1, Ar2 and Ar3 are each independently selected from the group consisting of formula (II).
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公开(公告)号：EP1322643A1
公开(公告)日：2003-07-02
申请号：EP01979304.1
申请日：2001-10-01
发明人： ZHU, Bing-Yan , SU, Ting , LI, Wenhao , GOLDMAN, Erick, A. , ZHANG, Penglie , JIA, Zhaozhong, Jon , SCARBOROUGH, Robert, M.
IPC分类号： C07D409/12 , C07D409/14 , C07D241/08 , C07D403/10 , C07D401/14 , C07D491/113 , C07D401/12 , C07D405/14 , A61K31/495 , A61P7/02
CPC分类号： C07D401/10 , C07D241/08 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D491/10
摘要： Novel piperazin-2-one containing compounds of general formulae (I) or (II), including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivative having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
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